Prohormone & Supplement Ingredients:

Sucralose (Splenda)

Sucralose is a zero calorie artificial sweetener discovered in 1976 and is 600 times sweeter than sugar. The human body doesn't metabolize sucralose, thus it does not any usable calories or energy. It is made from sugar by substituting three alcohol groups on the sugar molecule with three chlorine atoms to create sucralose.

Sucralose belongs to a class of compounds known as organochlorides (chlorocarbons). Some organochlorides are toxic. Sucralose is not known to be toxic in small quantities and doesn't accumulate in fat like chlorinated hydrocarbons.

Sucralose is an ingredient in more than 4,500 food and beverage products. Sucralose is one of two artificial sweeteners ranked as "safe" by the consumer advocacy group Center for Science in the Public Interest. Results from over 100 studies in the FDA approval process indicated a lack of risk associated with sucralose intake. Some adverse effects, however, were seen at doses significantly higher than the estimated daily intake of 1 mg/lb/day. The bulk of sucralose ingested is not absorbed by the gastrointestinal (GI) tract and is directly excreted in the feces. The amount that is absorbed from the GI tract (11 - 27%) is mostly removed by the kidneys and eliminated in the urine with an estimate 20-30% of the absorbed sucralose being metabolized.

A study found evidence that doses of Splenda equivalent to sucralose at 1.1 to 11 mg/kg reduced the amount of good bacteria in the intestines of rats by up to 50%, increased pH level in the intestines, contributed to increases in bodyweight, and affected the levels of P-glycoprotein. These effects have not been reported in humans. Other studies suggest sucralose as a possible trigger for some migraine patients and linked large doses of sucralose to DNA damage in mice.

Allergic reactions to sucralose have not been documented, but individuals sensitive to maltodextrin should consult a physician about using any sweeteners containing this bulking agent.
Supplements with this ingredient:
None (for now)

Links to additional information on Sucralose (Splenda)
A Report on Sucralose from the Food Sanitation Council (Added on 1/4/2011)
Sucralose: An Overview (Added on 1/4/2011)
Toxicity of sucralose in humans: a review (Added on 1/4/2011)
Sucralose safety 'scientifically sound': Expert panel (Added on 1/4/2011)

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