Prohormone & Supplement Ingredients:

Beta-Sitosterol (PYGEUM AFRICANUM)

Beta-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a characteristic odor. They are hydrophobic and soluble in alcohols.

Numerous plants contain cholesterol-like compounds called sitosterols and their close relatives sitosterolins. A special mixture of these called beta-sitosterol is used for the treatment of benign prostatic hyperplasia (BPH).Beta-sitosterol joins saw palmetto , pygeum , nettle , and grass pollen as a moderately well-documented treatment for BPH.

Alone and in combination with similar phytosterols, Beta-Sitosterol reduces blood levels of cholesterol, and is sometimes used in treating hypercholesterolemia. Beta-Sitosterol inhibits cholesterol absorption in the intestine. When the sterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. Phytosterols and phytostanols both inhibit the uptake of dietary and biliary cholesterol, decreasing the levels of LDL and serum total cholesterol. Because the structure of Beta-Sitosterol is very similar to that of cholesterol, Beta-Sitosterol takes the place of dietary and biliary cholesterol in micelles produced in the intestinal lumen. This causes less cholesterol absorption in the body.

A review of the literature, published in 1999, found a total of four double-blind placebo-controlled studies on beta-sitosterol for BPH, enrolling a total of 519 men. 4-7 All but one of these studies found significant benefits in both perceived symptoms and objective measurements, such as urine flow rate.

The largest study followed 200 men with BPH for a period of 6 months. 8 After the trial was completed, many of the participants were followed for an additional year, during which the benefits continued. 9 Similar results were seen in a 6-month, double-blind trial of 177 individuals. 10

Beta-sitosterol binds to prostate tissue and affects the metabolism of prostaglandins, substances found in the body that affect pain and inflammation. 1 However, it is not clear whether this is the correct explanation for how beta-sitosterol might help in BPH.

Supplements with this ingredient:
Elevated Organ Support (On Cycle Support)
Organ Shield (On Cycle Support)

Links to additional information on Beta-Sitosterol (PYGEUM AFRICANUM)
Beta Sisterol Wiki (Added on 5/9/2011)
Beta-sitosterol plant extract (Added on 5/9/2011)
Are Beta Sitosterol Tablets Safe to Take and Do They Lower Cholesterol? (Added on 5/9/2011)

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