Prohormone & Supplement Ingredients:

4-hydroxyandrostenedione (Formestane, Lentaron)

4-hydroxyandrostenedione (Formestane, Lentaron) is a steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.

Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.

4-hydroxyandrostenedione significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer.

In comparative studies, the clinical efficacy of intramuscular (injected) formestane 250mg did not differ significantly from that of oral megestrol when administered as second-line endocrine therapy to patients with advanced disease in whom previous tamoxifen therapy had failed.

Formestane produced a response rate, duration of response and overall survival rate that was not significantly different from that of oral tamoxifen when administered as first-line endocrine therapy to patients with advanced disease, but tamoxifen was superior in some measures.

Formestane is well tolerated by the majority of patients; adverse events rarely necessitate cessation of therapy. The systemic tolerability of formestane is similar to that of tamoxifen but better than that of megestrol.
Supplements with this ingredient:
None (for now)

Links to additional information on 4-hydroxyandrostenedione (Formestane, Lentaron)

No Informational URLS have been entered!
only members can suggest new info links