Xtreme Tren Six Information (Prohormones)

Xtreme Tren Six by


Ratings
Ingredients
Manufactured by:
Anabolic Technologies

Serving Size: 1 Capsule
Servings Per Container: 90

Ingredients:
Estra-4,9,11-Triene-3,17 Dione - 15mg (Trenavar)
6-chloro-androst-4-ene-3-one-17b-ol 30mg (Hexadrone)
Milk thistle (80% silymarin) 100mg
N-Acetyl-L-Cystine (NAC) 100mg
Tongkat Ali (Long Jack) 100mg

Other Ingredients: Gelatin, Silica, Magnesium Stearate, Stearic Acid.

Recommended use: Take 1 capsule 1 to 3 times per day. Do not take for more than 30 days consecutively. Take at least 90 days off before starting another cycle.

First thing I noticed here is the responsible recommendations for use. Do take for more than 30 days and follow with 90 DAYS OFF. I've always held up 2x as long off as one, and here's a company that goes even further. I like that.

Something to think about though. Both of these are pretty new. There still aren't a lot of logs and reviews out there, and no posted bloodwork from users. Hexadrone in particular is fairly untried.

Trenavar is supposed to be pretty strong stuff. I've seen some reported sides, especially some bad acne, associated with this. I'm reading about a tendency for bloat, which could mean bad news for blood pressure. I think this would be one you want to run solo before you try it stacked with another compound.

Both of these are unmethylated, but liver stress isn't the only side effect caused by prohormone and steroid use.

I don't see the support supplements as being a plus. I like to control my intake of support supplements seperately from the prohormone. Also, there's been some recent research indicating milk thistle might interfere with absorbtion.

Lonjack? Unproven.

NAC? Good stuff, take more.

This stack would definitely require perscription strength PCT.

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6-chloro-androst-4-ene-3-one-17b-ol (Hexadrone)

I'm afraid I'm not finding a lot of information on this compound, and this write up is composed of bits and pieces from various boards as posted by people a lot smarter then me (hi HenryV and Patrick Arnold!).

Now here's the PR write up from Shredded Labs for their Hexadrone product; please note that on the bottle the compound is listed as 6-chloro-androst-4-ene-3-one-17b-ol whereas in the write up it's written as 6a-chloro-androst-4-ene-3-one-17b-ol. You'll see why this matters later.

Here's the PR:

6a-Chloro-androst-4-en-17b-ol-3-one represents the next generation of legal androgens: Extremely effective, dry, and non-methylated, it stacks well with everything, and is more than adequate for solo runs.

Powerful anabolic, rated at 300: (anabolic:androgenic) vs. testosterone.

Cannot convert to estrogen; immune to the effects of aromatase.

Intrinsically active compound with no conversion required.

Non-methylated, yet resistant to some aspects of CYP-mediated metabolism due to the Chloro group at C6.

In terms of results, this 6-chlorinated compound is equal to harsher androgens such as M1, 4ADD and Halodrol. In terms of toxicity, this compound cannot even be compared to them. It's much safer and much milder.

Unfortunately we know Press Releases aren't always 100% accurate. Here are some bits and pieces for you:


From a Shredded Labs Rep (sound surprisingly straightforward):
...these claims of SD (Superdrol) gains or that its a new tren are ridiculous. I PERSONALLY feel that this compound will feel like a hybrid between Halo/Epi/Boldione. It does have AI properties and cannot convert to Estrogen like Epi. It is a powerful yet non-methylated compound like Boldione which is mild on the body and stacks well with methylated and other non-methylated compounds as well as being very efficient when used solo, and I believe that the results when ran solo will be comparable to similar dosages of Halo. It is not Superdrol and will not give you gains of 20lbs from a 4 week cycle, but it will also not wreak the havoc on your body or come with the sides of SD. It is not a progestin like Tren, it should not cause any of the "deca-dick" or "trensomnia" sides of progestins, but it will have similar recomposition potential.... Dosing should be about 100mg daily split evenly between the day.

onyop888 from ProhormoneForum.com:
From what I can gather it is supposed to be similar to a non-methylated halodrol.

HenryV from ProhormoneForum.com:
They don't indicate the orientation of the 6-chloro. The 6a-isomer (Vida S-29) is much stronger than the 6b (S-71). It is a non-methyl.

Patrick Arnoild on ProhormoneForum.com in response to it being viable as a steroid similar to hdrol:
probably not as an oral. hdrol is methylated

When I search for Hexadrone there's even less info. Shredded Labs seems to be a real company, but I didn't find listing for Hexadrone on their site (although they seeem to have plenty of other goodies....)

Estra-4,9,11-triene-3,17-dione (Trenavar)

Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.

From HenryV:

Function:

This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.

Structure:

This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.

Effects:

Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.

Side Effects:

Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.

Metabolism and Bioavailability:

The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes [1], and also because trenbolone is an antagonist of the glucocorticoid receptor [2]. The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific [3]. Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?

The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats [4], and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.


Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<

Gelatin

Gelatin is a tasteless substance created from collagen found in animal skin and bones. It is used to thicken liquid in processed foods as well as having applications in photography, cosmetics, and pharmaceuticals. Gelatin is found in many forms of candy, marshmallows, Jell-O, and some types of yogurt. Gelatin can be bought in many grocery stores for use in home cooking. In the vast majority of cases, gelatin is not harmful to the consumer.

Long Jack (Eurycoma Longifolia, Tongkat Ali, Pasak Bumi)

Long Jack (Eurycoma longifolia - commonly called tongkat ali or pasak bumi) is a flowering plant in the family Simaroubaceae, native to Indonesia, Malaysia, and, to a lesser extent, Thailand, Vietnam, and Laos.

Even though there are other legitimate medical areas of interest in Eurycoma longifolia, most Southeast Asians consume it for the plant's impact on sexual conduct. Already in 2001, Malaysian scientific researchers opened their peer-reviewed, Medline-archived report on Eurycoma longifolia's effect on lab rats with the statement "that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities."

Some scientific studies found that it enhances sexual characteristics and performance in rodents. Other laboratory animal tests have produced positive indications, with one extract having been observed to increase sexual activity in mature rats, including arousal, sniffing, and mounting behavior. In an experiment conducted on male rats, it was found that eurycoma longifolia increases sperm count. The authors also reported that the plasma testosterone level of Eurycoma longifolia extract treated rats "was significantly increased when compared with that of the control and infertile animals."

Another group of scientists confirmed that Eurycoma longifolia has the capacity to "reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis." One Medline-indexed journal article cited as result that Eurycoma longifalia had an effect similar to testosterone replacement therapy in counteracting ostereoposis.

In a placebo-controlled human study with healthy young men in a weight-training program, it was found that "the lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012)." The results of the study were published in the peer-reviewed British Journal of Sports Medicine.

The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. "Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator ani muscle".

Because of Eurycoma longifolia's testosterone-enhancing capacity, it has been included in numerous supplements marketed primarily to body building men. In gym circles, Eurycoma longifolia Jack is commonly referred to as Longjack.

Magnesium Stearate

Magnesium stearate is often used as a diluent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets.

Magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, but not that it reduces the over-all bioavailability of those ingredients.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.

Silicon Dioxide (Silica)

The chemical compound silicon dioxide, also known as silica, is an oxide of silicon. Silica is most commonly found in nature as sand or quartz.

Silica is common additive in the production of foods, where it is used primarily as a flow agent in powdered foods, or to absorb water in hygroscopic applications. It is the primary component of diatomaceous earth which has many uses ranging from filtration to insect control. It is also the primary component of rice husk ash which is used, for example, in filtration and cement manufacturing.

Stearic Acid

Stearic acid is the saturated fatty acid with an 18 carbon chain and has the IUPAC name octadecanoic acid. It is a waxy solid, and the salts and esters of stearic acid are called stearates. It occurs in many animal and vegetable fats and oils, but it is more common in animal fat. The important exceptions are cocoa butter and shea butter, whose fatty acids consist of 2845% stearic acid.

Stearic acid is used in making candles, plastics, dietary supplements, oil pastels and cosmetics, softening rubber, and hardening soaps. Stearic acid is used in aerosol shaving cream products. It is used along with simple sugar or corn syrup as a hardener in candies and to form margarines, shortenings, spreads, and as a cream base for baked products.

Even though stearic acid is a saturated fat, studies have suggested that it has little effect on blood cholesterol levels, because such a high proportion is converted to oleic acid.