Xtreme Tren SD Information (Prohormones)

Xtreme Tren SD by


Ratings
Ingredients
Manufactured by:
Anabolic Technologies

Serving Size: 1 Capsule
Servings Per Container: 90

Active Ingredients
2a, 17a-dimethyl-17B-hydroxy-5a-etiocholan-3-one (Superdrol) - 12mg
Estra -4,9,11-Triene-3,17 Dione (Trenavar) - 15mg

Other Ingredients
Milk thistle (80% silymarin) - 100mg
N-Acetyl-L-Cystine (NAC) - 100mg
Tongkat Ali (Long Jack) - 100mg

I couldn't find the recommended use listed anywhere, so I'll just post this:

Superdrol
Methyl
Low - 10mg daily
Average - 20mg daily
High - 30mg daily
Recommended Cycle length: 3-4 weeks

Trenevar
Non-methyl
Low - 60mg daily
Average - 90mg daily
High - 120mg daily
Recommended Cycle length: 4-7 weeks

This stack doesn't seem to well thought out when you consider the above. Trenevar is way underdosed. Both Trenevar and Superdrol have a reputation for gyno, so there's another reason to not to put them together.

The Superdrol nomenclature listed for Xtreme Tren SD is 2a,17a-dimethyl-17B-hydroxy-5a-etiocholan-3-one, which is one I didn't have in the database. It differs only slightly from 2a,17a-dimethyl-17a-hydroxy-5a-etiocholan-3-one, the difference being 17a versus 17b.

A quick search did show the nomenclature 2a,17a-dimethyl-17B-hydroxy-5a-etiocholan-3-one as being identified as Superdrol though. With the way supplement companies write things to avoid FDA bans, maybe it's on purpose?

I also saw two formulations for Xtreme Tren, with teh other one replacing Superdrol with Hexadrone. A few places advertised Xtreme Tren SD, but were selling the new formula. Try to get a look at the bottle before you buy to make sure it's the Superdrol version (if that's what you want).

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2a,17a-dimethyl-17a-hydroxy,5a-etiocholan-3-one (Superdrol)

Seems to be yet another chemical nomenclature for Superdrol:

2a,17a-dimethyl-5a-androst-3-one-17b-ol (Superdrol)
2a,17a-dimethyl-17b-Hydroxy-5a-androstan-3-one
(Superdrol)


Superdrol is a powerful anabolic designer steroid brought to market in 2005, however due pressure by the FDA, the original Superdrol was pulled and is no longer available. Like many other compounds, it has been made available again through the production of clones.

Estra-4,9,11-triene-3,17-dione (Trenavar)

Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.

From HenryV:

Function:

This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.

Structure:

This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.

Effects:

Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.

Side Effects:

Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.

Metabolism and Bioavailability:

The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes [1], and also because trenbolone is an antagonist of the glucocorticoid receptor [2]. The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific [3]. Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?

The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats [4], and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.


Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<

Long Jack (Eurycoma Longifolia, Tongkat Ali, Pasak Bumi)

Long Jack (Eurycoma longifolia - commonly called tongkat ali or pasak bumi) is a flowering plant in the family Simaroubaceae, native to Indonesia, Malaysia, and, to a lesser extent, Thailand, Vietnam, and Laos.

Even though there are other legitimate medical areas of interest in Eurycoma longifolia, most Southeast Asians consume it for the plant's impact on sexual conduct. Already in 2001, Malaysian scientific researchers opened their peer-reviewed, Medline-archived report on Eurycoma longifolia's effect on lab rats with the statement "that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities."

Some scientific studies found that it enhances sexual characteristics and performance in rodents. Other laboratory animal tests have produced positive indications, with one extract having been observed to increase sexual activity in mature rats, including arousal, sniffing, and mounting behavior. In an experiment conducted on male rats, it was found that eurycoma longifolia increases sperm count. The authors also reported that the plasma testosterone level of Eurycoma longifolia extract treated rats "was significantly increased when compared with that of the control and infertile animals."

Another group of scientists confirmed that Eurycoma longifolia has the capacity to "reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis." One Medline-indexed journal article cited as result that Eurycoma longifalia had an effect similar to testosterone replacement therapy in counteracting ostereoposis.

In a placebo-controlled human study with healthy young men in a weight-training program, it was found that "the lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012)." The results of the study were published in the peer-reviewed British Journal of Sports Medicine.

The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. "Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator ani muscle".

Because of Eurycoma longifolia's testosterone-enhancing capacity, it has been included in numerous supplements marketed primarily to body building men. In gym circles, Eurycoma longifolia Jack is commonly referred to as Longjack.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.