Sasquatch DNA Pure Mass Information (Prohormones)

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Xcel Sports Nutrition

Sasquatch DNA Pure Mass by Xcel Sports Nutrition may be considered by many to be the best and strongest pro hormone to hit the market in 2013. The ingredient panel alone is enough to make you want to pound your chest like a 500 pound gorilla?ok, or a Sasquatch! Yes, we said it.

It is clear that they took a great deal of time and paid attention to detail when creating this formula. Although there are many ingredients in the stack, we don?t feel that it is over-dosed. In fact, we consider the dosages to be right in line with a pro hormone cycle. As always, Sasquatch DNA Pure Mass contains Xcel?s signature Carbopol polymer which helps the time-released aspect.

When running these compounds alone, you would potentially take higher amounts, but since they are stacked with some other heavy-hitters, the dosages are cut down a bit.
Deca can take a while to kick in, however, it is very anabolic.

M1, 4ADD is a precursor to Dianabol, and is very effective, yet a bit wet, so the built-in liver support and estrogen control compliment this one nicely.

Cyanostane is great for putting on mass and strength. This is a compound similar to Superdrol, however, is much dryer, and has very little water retention.

Dimethazine, DMZ, or D-Zine is again popular due to good results, and very little sides.

As always, it is recommended that cycle support and PCT be taken properly while on this stack. Additionally, this stack is only recommended for advanced athletes ? no beginners welcome. Methylated pro hormones should always be taken as recommended.

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17a-methyl-1,4-androstadiene-3,17diol (M1,4ADD)

M1,4ADD is a prohormone of Dianabol, but is similar in structure to and said to act more like boldenone. When taken orally, 17a-methyl-1,4-androstadiene-3,17diol (M-1,4ADD) is converted by the enzyme 3HSD into dihydroboldenone. Recommended dosages are 30-90mg daily with cycles averaging 4-5 weeks in length. M1,4ADD isn?t recommended for first time pro-hormone and steroid users.

M1,4ADD has some conversion (around 15%) to Dianabol (methandrostenolone). It's been reported that despite conversion to Dianabol, the on-cycle feeling and results more closely resemble Boldione (Bold/1,4AD).

M1,4ADD is a wet (aromatizes) compound. Users can expect some estrogen related sides such as water retention, bloating and irritation or reappearance of existing gyno. It is common to use an AI to suppress estrogen while on cycle.

17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine (Dymethazine)

Trade Name: Dymethazine

Dymethazine (aka mebolazine) was brought to market by iForce Nutrition in 2009, however, despite Dymethazine being 'legal' it was largely taken off the market due to recent FDA activities. Despite this, clones of the original Dymethazine have already been brought to the market. Dymethazine and DZine are interchangeable featuring the same compound (2,17-dimethyl-5-androstan-17-ol-3,3-one-azine)

Dymethazine is an azine, two superdrol molecules attached to each other by a nitrogen atom. Stomach acid separates the two superdrol molecules from each other, after which they make their way to the androgen receptors. Dymethazine is also known as mebalozine.

Dymethazine is nearly identical to Superdrol, except it's two (as opposed to one) superdrol molecules attached to each other. Your body's stomach acid separates these two molecules prior to absorption, so it becomes a single molecule with two potential pathways. Despite this difference, Superdrol remains the more powerful compound.

The one advantage Dymethazine has over Superdrol is the lower likelihood/greater managability of side effects. Dymethazine is an incredibly potent compound and carries the same risks as any other powerful anabolic steroid or pro-hormone.

In a study, patients were administered Dymethazine for 45+ days. Liver values did not change for 50% of patients, while the other 50% noticed only modest to moderate increases in liver values. So, while Dymethazine can increase liver values, it is not as harsh as the current strong methyls currently available.

Dymethazine features 0% ability to aromatize and expresses an extremely weak androgenic activity. This means Dymethazine will produce gain with little to no liver impact and will cause no estrogen related side effects.

18-methylestr-4-en-3-one-17b-ol

I'm afraid I can't find much on this....

Patrick Arnold, acknowledged as the defacto father of prohormones, had this to say:

"that's the same as
13[beta]-ethyl-17[beta]-hydroxygon-4-en-3-one
which is a controlled substance in many states

"it should be a controlled substance nationally but since the people that wrote the 2004 anabolic steroid control act screwed up royally they put alpha where they should have put beta. so they ended up banning a useless steroid instead of the one they meant to

"I dunno if that typo ever was resolved, or if a typo is grounds enough to cover your ass. I wouldn't risk it if i were considering selling the stuff"

also

"it was made a controlled substance in 2005 i believe. Its basically norbolethone without the 17a-ethyl. Its also the thing that the prohormone that i forgot they call converts to. you know, the gona-2,5(10)-diene crap or whatever"

and on the nomenclature

"13-ethyl-gon and 18-methyl-estr both mean the same thing"

2-cyano-17a-methyl-17b-hydroxy-androst-3-one (Cyanostane)

Also called Cynabol

Cyanostane is a new prohormone which features an alteration of the superdrol compound, with a cyano bond instead of the 2a methyl superdrol bond. It's relatively new with few reviews.

The chemical structure is the same as methyldrostanolone (Superdrol), except it has a cyano group on the 2 position instead of a methyl group. It is a C-17aa steroid and it will be liver toxic, although, due to the lack of the 4-ene on ring A and lack of 2-methylation, liver toxicity may be reduced relative to a di-methylated steroid such as Superdrol.

Expected results would be lean gain as this compound cannot convert to estrogen. Based on the chemical structure the anabolic potency would appear to be fairly potent with moderate androgenic potency.

There seems to be a nomenclature mistake on the labeling for this steroid. The chemical name contains the term "androst", assuming that there is some sort of ene group on ring A. But there does not seem to be such mention of an ene group on ring A. Therefore, the term androst should be androstan. But if this is the case, the 2-cyano group needs to be stated as alpha or beta. This makes a big difference, since usually C2-alpha groups are significantly more effective than beta.

There are studies about other 2-cyano steroids such as 2-cyano-DHT and 2-cyano-progesterone. In separate studies, one done on dogs, it was seen that both of these 2-cyano steroids caused inhibition of 3b-HSD enzyme. This inhibition would cause severe adrenal suppression. This is a very unsafe inhibition. Whether it occurs in this cyano steroid is unknown, but users need to be aware of this possibility.

5a-Hydroxy Laxogenin

5a-Hydroxy Laxogenin was discovered in 1996 and shown to have an anabolic/androgenic ratio similar Anavar, but without the side effects of liver toxicity or testing positive for steroidal therapy. Athletes claim to have seen strength increases in 3-5 days, and muscle mass increases in 3-4 weeks.
AKA Laxogenin

This ompound has shown up as a standalone in Anabolica and Zoe's Ecdysterone.

5a-hydroxy-laxogenin is a steroidal sapinogen, although whether or not it is the desired laxinogen is a mystery since no lab standard for it is available, nor was it referenced within the GCMS library.

Marketing claims for this compund say it is the only product ever designed to increase mass and strength without steroidal influence and that it doesn't test positive for steroids.

Tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.

It's also been shown to balance cortisol on calorie restricted diets, helps control glucose and increases thyroid function.

Drips and Drabs pulled from the Internets....

"Laxogenin does indeed have some pretty profound anti-inflammatory effects. In addition to being able to be synthesized from Diosgenin, it is a component of smilax sieboldii."

"Laxogenin is a steroidal sapogenin isolated from Smilax sieboldi. As a spirostanic analogue of the brassinosteroid - teasterone, Laxogenin is noted for it's growth promoting activity [in plants]. It has also been demonstrated to aquire [cytotoxic] properties however, to what degree, I am not sure. In contrast, Laxogenin was demonstrated to aquire antitumor-promoting activity in a two-stage lung carcinogenesis experiment."

"The best (published) study can be found in the journal Phytochemistry, 1971, vol. 10, pp 1339-1346. Again in 1989, same journal vol. 28, no. 9 pp 2509-2511 (laxogenin acetate). There is reference going back to 1965 in Chem. Pharm. Bull. 13(5), pp. 545-550 (laxogenin).

It was Syrov's paper of 1976 though, appearing in Farmakol, Toksikol that really sparked my interest. The paper is entitled, "An Experimental Study on the Anabolic Activities of 6-keto Derivatives of some natural sapogenins".

It details the 4 sapogenins (referred to as compounds 1-4 in the Soviet Union) and gives source material, results of the classic steroid model (levator ani studies) and mentions other clues critical to their use. Most of these compounds can be derived from Diosgenin (so can testosterone).

Laxogenin appears closest to Compound 2, the most desirable of these. Thermo includes it as 25R in their formulation and I very much wish it were available as a standalone. I can tell you from experience that when you get the right Laxogenin, it for sure delivers on the recovery, anti-inflammatory etc. side of things and is a superb regenerative agent.

NoHype, I would be most interested in your opinions in the event you do a deeper dive as I believe the compound holds great promise."

6-Bromoandrostenedione

I've been confusing myself again.

There's the compound 6-Bromodione which binds to the aromatase enzyme making it unable to convert androgens to estrogen.

6-alpha-Bromodione is a fast acting competitive inhibitor of the aromatase enzyme. It works by binding to the aromatase enzyme to prevent it from aromatizing androgens. This is not a permanent binding and later acts to normalize aromatase (and thus estrogen levels) as hormone production returns to normal. It specifically targets aromatase and does not act as a central anti-androgen like some other post cycle products can. This means that your libido and mood will not be negatively affected.

6-beta-Bromodione works in a similar way but has an irreversible and permanent effect. This works well to mediate the excess aromatase that was produced while on cycle, while the alpha isomer works to normalize the natural levels. The goal is again to transition into normal production levels for all hormones affected by the anabolic cycle.

I found "6-bromoandrostenedione vs. 6 Bromodione" and says: "They are the same thing; I think it also goes by "6-bromolane. I would imagine that products containing 6-bromodione would be a mixture of alpha and beta, given the expense associated with separation. Also, 6-alpha-bromodione should convert into 6-alpha-bromo-testosterone, which should be a relatively potent anabolic steroid. So, if taken for PCT, it could actually be suppressive (like epistane, which is both an AI and suppressive steroid). Actually, I bet 6-alpha-bromodione would make a decent PH.

I think 4-HO-androstenedione has been researched more, but both could probably lower androstenedione production."

Carbopol

Carbopol is a registered trademark of The Lubrizol Corporation for a family of polymers used as thickeners, suspending agents and stabilizers.

Carbopol is used as a thickening agent in lotions, creams and gels. It is also used to stabilize, suspend, and control the release of pharmaceutical products (time release).

Different varieties produce varying viscosities, but most are used below 1% concentration. The crosslinked polymers are not actually water soluble, but swell into hydrated spheres that are the source of it's thickening action.

Long Jack (Eurycoma Longifolia, Tongkat Ali, Pasak Bumi)

Long Jack (Eurycoma longifolia - commonly called tongkat ali or pasak bumi) is a flowering plant in the family Simaroubaceae, native to Indonesia, Malaysia, and, to a lesser extent, Thailand, Vietnam, and Laos.

Even though there are other legitimate medical areas of interest in Eurycoma longifolia, most Southeast Asians consume it for the plant's impact on sexual conduct. Already in 2001, Malaysian scientific researchers opened their peer-reviewed, Medline-archived report on Eurycoma longifolia's effect on lab rats with the statement "that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities."

Some scientific studies found that it enhances sexual characteristics and performance in rodents. Other laboratory animal tests have produced positive indications, with one extract having been observed to increase sexual activity in mature rats, including arousal, sniffing, and mounting behavior. In an experiment conducted on male rats, it was found that eurycoma longifolia increases sperm count. The authors also reported that the plasma testosterone level of Eurycoma longifolia extract treated rats "was significantly increased when compared with that of the control and infertile animals."

Another group of scientists confirmed that Eurycoma longifolia has the capacity to "reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis." One Medline-indexed journal article cited as result that Eurycoma longifalia had an effect similar to testosterone replacement therapy in counteracting ostereoposis.

In a placebo-controlled human study with healthy young men in a weight-training program, it was found that "the lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012)." The results of the study were published in the peer-reviewed British Journal of Sports Medicine.

The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. "Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator ani muscle".

Because of Eurycoma longifolia's testosterone-enhancing capacity, it has been included in numerous supplements marketed primarily to body building men. In gym circles, Eurycoma longifolia Jack is commonly referred to as Longjack.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.