Reaper Information (Prohormones)
Xcel Sports Nutrition
Reaper Supplement Facts
Serving Size: 1 Capsule
Servings per Container: 60
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol - 150mg (Furazadrol)
2a,3a-epithio-17a methyl-17b-hydroxy-5a-androstane - 40mg (Epistane)
Estra-4,9,11-triene-3,17-dione ? 20mgs ? 25mg (Trenavar)
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol ether - 50mg (Orastan-A)
Androsta-3,5-diene-7,17-dione - 25mg (Arimistane)
5A-Hydroxy Laxogenin - 25mg
Carbopol ? 15mg
Milk thistle (80% silmarin) - 100mg
N-Acetyl-L-Cystine (NAC) - 100mg
Tongkat Ali (Long Jack) - 100mg
I'm going to start here on this:
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol - 150mg (Furazadrol)
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol ether - 50mg (Orastan-A)
Notice anything? Yep, they are the same thing. Orastan-A is what Furazadrol used to be called. From Tuned Sports:
Orastan-A is an off shoot legal variation of Furzabol.... the Orastan-A compound was brought to market by Gaspari Nutrition back in 2006.... Since then many different clones have been brought to market that offer similar results to the original Orastan-A; Competitive Edge Labs ? Furuza-A, Axis Labs ? Furazadrol, Winabol/Winadrol, Spectra Force Research Furaguno, Other less popular include Furazavol and Winzrol, generally anything in the "Fura" or "Win" naming scheme might be an Orastan-A clone.... The nomenclature for these clones is typically either (5a-androstanol[2,3]furazan-17b-tetrahydropyranol) or (5a-etioallocholan(2,3-)furazan-17b-tetrahydropyranol), both compounds will produce nearly identical results....
In light of the above, when I look at the ingredients list for Reaper, I'm seeing that it's lists the same compound two times, once as Furazadrol at a dosage of 150mg and then again as Orasten-A with a dosage of 50mg. In looking at how they wrote the nomenclature, the only difference between the two is the additon of "ether" on the Orasten-A.
Also, the nomenclature they use for Epistane is incomplete.
Stuff like this bugs me. Thi sis a supplement I'm (potentially) going to ingest taht could have pretty serious effects on my pysiology. Can I trust a company that is either being willfully disengenuous or lacks attantion to detail? The doubt these questions raise would be enough for me to pass on this one until it gets sorted out.
This is a fairly new release (March 2013) so as of yet I'm not seeing it in too many online retailers. Nor am I seeing any dosage recommendations. Given that, I can only assume that the dosages listed above are for one capsule. With Epistane, 40mg is considered pretty close to the high end. Most users hand around 30, maybe finish at 40, with only a few going beyond that. Combining the Fruza and Orasten-A give us 200mg, pretty close to the most common does of 250mg. Trenavar is low at 25 (60 being the usual).
You can read about hte support supp added in above. Although I didn't read anything about it being time release, the addition of the Carbopol makes me think that is the manufactures intent. NAC is a great anti-oxident, Longjack unproven, Milk Thistle good for the liver (although now there's some question as to whether it inhibits the conversion of prohormones), 5A-Hydroxy Laxogenin still being logged (some say great stuff, some not so much), and the Arimistane an unproven anti-estrogen.
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol (Havoc/Epistane)Also written as: 2a,3a-epithio-17a-methyl-17b-hydroxy-5a-adrostan
Trade names include Havoc/Epistane
Common Dosages: 30mg to 40mg daily
Common Cycle Length: 4-5 Weeks
Half-Life: Average (6-8 hours)
A designer steroid and legal alternative to anabolic and androgenic steroids.
Epistane is a methylated version of the controlled substance Epitiostanol (2±,3±-Epithio-5±-androstan-17²-ol), created in the 1960's and used as a treatment for breast cancer. Chemists added a methyl group to the compound to create the product known as Epistane. Epistane is a sulfur containing steroid which is known to have strong and long lasting anti-estrogenic activity as well as weak androgenic and mytropic activities.
Since it is anti-estrogenic, you can expect very dry gains from this compound. Epistane has low androgenic to anabolic activity, meaning it is much more anabolic then androgenic. Even though users will see dry gains on Epistane it does not mean that it would be any insufficient for a bulking cycle.
Side effects are typically minimal to non existent.
5a-androstanol[2,3]furazan-17b-tetrahydropyranol (Furazadrol)Trade names include Orastan-A, Furaguno, Furazadrol, Furuza-A, Winabol/Winadrol, Katanadrol 2.0
Additional nomenclature: 5a-etioallocholan(2,3-)furazan-17b-tetrahydropyranol
Common Dosages: 200mg to 300 mg daily.
Common Cycle Length: 5-6 Weeks.
Orastan-A is an off shoot legal variation of which is structurally similar to an old and no longer available Japanese steroid called Furzabol.
Furazabol, also sold under the name Miotolan, was rarely seen outside of Japan. Furazabol is a fairly potent oral anabolic steroid, with properties somewhat similar to its close cousin Winstrol (stanozolol). This compound is a non-methylated derivative of furazabol, and as a result may share certain functional characteristics to this agent.
There are many different on the market that offer similar results to the original Orastan-A:.
This compound is on the mild side. It's also non-methylated therefore liver issues aren't a usually a concern. It is seldom used for bulking and tends to be more appropriate for recomping (building muscle while losing fat) or cutting. It's also a good compound to stack due to it being non-methylated.
There's a reputation for a unique potency toward increasing androgen receptor density, suggesting it can be used to intensify the anabolic effects of other steroids. Such a connection can't be substantiated by the literature. Any effect it has on androgen receptor density likely mimics those of other anabolic steroids, which may include some period of upregulation.
Overall one can expect this to be a mild to moderately effective anabolic, with low relative androgenicity. It presents minimal liver toxicity, but could negatively affect cholesterol levels.
5a-Hydroxy Laxogenin5a-Hydroxy Laxogenin was discovered in 1996 and shown to have an anabolic/androgenic ratio similar Anavar, but without the side effects of liver toxicity or testing positive for steroidal therapy. Athletes claim to have seen strength increases in 3-5 days, and muscle mass increases in 3-4 weeks.
This ompound has shown up as a standalone in Anabolica and Zoe's Ecdysterone.
5a-hydroxy-laxogenin is a steroidal sapinogen, although whether or not it is the desired laxinogen is a mystery since no lab standard for it is available, nor was it referenced within the GCMS library.
Marketing claims for this compund say it is the only product ever designed to increase mass and strength without steroidal influence and that it doesn't test positive for steroids.
Tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.
It's also been shown to balance cortisol on calorie restricted diets, helps control glucose and increases thyroid function.
Drips and Drabs pulled from the Internets....
"Laxogenin does indeed have some pretty profound anti-inflammatory effects. In addition to being able to be synthesized from Diosgenin, it is a component of smilax sieboldii."
"Laxogenin is a steroidal sapogenin isolated from Smilax sieboldi. As a spirostanic analogue of the brassinosteroid - teasterone, Laxogenin is noted for it's growth promoting activity [in plants]. It has also been demonstrated to aquire [cytotoxic] properties however, to what degree, I am not sure. In contrast, Laxogenin was demonstrated to aquire antitumor-promoting activity in a two-stage lung carcinogenesis experiment."
"The best (published) study can be found in the journal Phytochemistry, 1971, vol. 10, pp 1339-1346. Again in 1989, same journal vol. 28, no. 9 pp 2509-2511 (laxogenin acetate). There is reference going back to 1965 in Chem. Pharm. Bull. 13(5), pp. 545-550 (laxogenin).
It was Syrov's paper of 1976 though, appearing in Farmakol, Toksikol that really sparked my interest. The paper is entitled, "An Experimental Study on the Anabolic Activities of 6-keto Derivatives of some natural sapogenins".
It details the 4 sapogenins (referred to as compounds 1-4 in the Soviet Union) and gives source material, results of the classic steroid model (levator ani studies) and mentions other clues critical to their use. Most of these compounds can be derived from Diosgenin (so can testosterone).
Laxogenin appears closest to Compound 2, the most desirable of these. Thermo includes it as 25R in their formulation and I very much wish it were available as a standalone. I can tell you from experience that when you get the right Laxogenin, it for sure delivers on the recovery, anti-inflammatory etc. side of things and is a superb regenerative agent.
NoHype, I would be most interested in your opinions in the event you do a deeper dive as I believe the compound holds great promise."
Androsta-3,5-Diene-7,17-Dione (Arimistane)This is being marketed as an Armoatase Inhibitor (AI) and cortisol inhibitor.
It's a metabolite of 7-Keto DHEA. The usual dosage of 7 Keto is 100-200mg, but this is not 7 Keto, it is 7 Keto DHEA. They're different.
This from Patrick Arnold over at Prohormoe Forum.com:
"The whole family of 7-oxygenated dhea metabolites are fascinating compounds, for many reasons other than aromatase inhibition. The compound under discussion here is not a major metabolite though, and so its very unlikely you could acheive therapeutic drug levels in your body by ingesting any reasonable amount of 7-keto"
From all the research I did, it would appear as though the jury is still out on this as far as to whether or not it actually does what the marketers claim.
There were some in vitro (lab test) that show AI properties, but no studies yet as to whether or not it translates into real life.
CarbopolCarbopol is a registered trademark of The Lubrizol Corporation for a family of polymers used as thickeners, suspending agents and stabilizers.
Carbopol is used as a thickening agent in lotions, creams and gels. It is also used to stabilize, suspend, and control the release of pharmaceutical products (time release).
Different varieties produce varying viscosities, but most are used below 1% concentration. The crosslinked polymers are not actually water soluble, but swell into hydrated spheres that are the source of it's thickening action.
Estra-4,9,11-triene-3,17-dione (Trenavar)Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.
Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.
This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.
This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.
Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.
Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.
Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.
Metabolism and Bioavailability:
The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes , and also because trenbolone is an antagonist of the glucocorticoid receptor . The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific . Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?
The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats , and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.
Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<
Long Jack (Eurycoma Longifolia, Tongkat Ali, Pasak Bumi)Long Jack (Eurycoma longifolia - commonly called tongkat ali or pasak bumi) is a flowering plant in the family Simaroubaceae, native to Indonesia, Malaysia, and, to a lesser extent, Thailand, Vietnam, and Laos.
Even though there are other legitimate medical areas of interest in Eurycoma longifolia, most Southeast Asians consume it for the plant's impact on sexual conduct. Already in 2001, Malaysian scientific researchers opened their peer-reviewed, Medline-archived report on Eurycoma longifolia's effect on lab rats with the statement "that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities."
Some scientific studies found that it enhances sexual characteristics and performance in rodents. Other laboratory animal tests have produced positive indications, with one extract having been observed to increase sexual activity in mature rats, including arousal, sniffing, and mounting behavior. In an experiment conducted on male rats, it was found that eurycoma longifolia increases sperm count. The authors also reported that the plasma testosterone level of Eurycoma longifolia extract treated rats "was significantly increased when compared with that of the control and infertile animals."
Another group of scientists confirmed that Eurycoma longifolia has the capacity to "reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis." One Medline-indexed journal article cited as result that Eurycoma longifalia had an effect similar to testosterone replacement therapy in counteracting ostereoposis.
In a placebo-controlled human study with healthy young men in a weight-training program, it was found that "the lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012)." The results of the study were published in the peer-reviewed British Journal of Sports Medicine.
The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. "Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator ani muscle".
Because of Eurycoma longifolia's testosterone-enhancing capacity, it has been included in numerous supplements marketed primarily to body building men. In gym circles, Eurycoma longifolia Jack is commonly referred to as Longjack.
Milk Thistle (SILYMARIN)The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.
The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.
Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.
Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".
A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.
A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective, while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.
Beside benefits for liver disease, other unproven treatment claims include:
Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage
Lowering cholesterol levels
Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
Reducing the growth of cancer cells in breast, cervical, and prostate cancers.
Used in many products claiming to reduce the effects of a hangover
Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.
Reducing liver damaging effects of chemotherapeutic drugs
Clinical study has shown that liver function tests can be improved in active hepatitis patients.
N-acetyl-L-cysteine (NAC)Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.
Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.
NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.
The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.