Pro Trenazine Information (Prohormones)

Pro Trenazine by


Ratings
Ingredients
Manufactured by:
Helica Pharm

Ingredients:
Estra-4,9,11-triene-3.17-dione - 20mg (Trenavar)
17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine - 10mg (Dymethazine)

Manufacturer recommended use: Empirical evidence is the only way to determine this; once the product has been used by enough people we’ll have a better idea of how much, and for how long, Pro Trenazine is best used. However, due to recent logs it appears 20mg three times per day is a good starting dose.

So by default I'm going to assume by recommending 3 caps per day for the Trenavar dosage automatically works out to 30mg of Dymethazine.


Trenavar is not a methyl, but has been noted for a decently high occurrence of sides, including elevated blood pressure and cholesterol levels; liver function markers are likely to be adversely affected. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production, and it would be sensible to assume that these may also result from use of Pro Trenazine.

Dymethazine is a methyl. As far as sides, tends to be hit or miss (same for effectiveness). Some users see sides, some don't, some see great results, some don't.

Know how you respond to each of these individually before you go taking the two together. For some users, this would probably be a pretty good combination.

Trenavar (Estra-4,9,11-triene-3,17-dione) made its debut in late 2011, touted as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

"Sweet spot" for Trenavar out in the wild is reported to be at 90mg a day, right between the 80-100mg you'd get for 4/5 caps here. From my research, 40-50mg a day of Dymethazine would be on the high high side. Recommendations generally say start at 15mg a day and work up to 30mg, with advanced users maybe hitting 45.

Member Rating for Pro Trenazine
Strength (higher = better)Size (higher = better)
only members can rateonly members can rate
Current Rating: n/a
Current Rating: n/a
Cutting (higher = better)Sides (lower = better)
only members can rateonly members can rate
Current Rating: n/a
Current Rating: n/a
Overall Rating: Not Rated

17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine (Dymethazine)

Trade Name: Dymethazine

Dymethazine (aka mebolazine) was brought to market by iForce Nutrition in 2009, however, despite Dymethazine being 'legal' it was largely taken off the market due to recent FDA activities. Despite this, clones of the original Dymethazine have already been brought to the market. Dymethazine and DZine are interchangeable featuring the same compound (2,17-dimethyl-5-androstan-17-ol-3,3-one-azine)

Dymethazine is an azine, two superdrol molecules attached to each other by a nitrogen atom. Stomach acid separates the two superdrol molecules from each other, after which they make their way to the androgen receptors. Dymethazine is also known as mebalozine.

Dymethazine is nearly identical to Superdrol, except it's two (as opposed to one) superdrol molecules attached to each other. Your body's stomach acid separates these two molecules prior to absorption, so it becomes a single molecule with two potential pathways. Despite this difference, Superdrol remains the more powerful compound.

The one advantage Dymethazine has over Superdrol is the lower likelihood/greater managability of side effects. Dymethazine is an incredibly potent compound and carries the same risks as any other powerful anabolic steroid or pro-hormone.

In a study, patients were administered Dymethazine for 45+ days. Liver values did not change for 50% of patients, while the other 50% noticed only modest to moderate increases in liver values. So, while Dymethazine can increase liver values, it is not as harsh as the current strong methyls currently available.

Dymethazine features 0% ability to aromatize and expresses an extremely weak androgenic activity. This means Dymethazine will produce gain with little to no liver impact and will cause no estrogen related side effects.

Estra-4,9,11-triene-3,17-dione (Trenavar)

Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.

From HenryV:

Function:

This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.

Structure:

This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.

Effects:

Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.

Side Effects:

Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.

Metabolism and Bioavailability:

The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes [1], and also because trenbolone is an antagonist of the glucocorticoid receptor [2]. The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific [3]. Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?

The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats [4], and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.


Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<