Organ Shield Information (On Cycle Support)

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Ingredients
Manufactured by:
Advanced Performance Supplements (APS)

Serving Size: 2 capsules
Servings per Container: 30

Ingredients:
Milk Thistle (standarized for 80% silymarin) 300mg
Beta-Sitosterol (Pygeum africnum) 250mg
Saw Palmetto (Serenoa Repens) (berries) 200mg
N-Acetyl-L-Cysteine (NAC) 250mg
Alpha Lipoic Acid (ALA) 150mg
Quercitin Dihydrate 150mg
Coenzyme Q-10 (CoQ10) (trans-isomer) 100mg

Organ Shield was designed to support, protect, and restore hepatic (liver), prostatic (prostate), and cardiovascular (heart) function during times of high stress, such as when using prohormones or steroids. This blend of specific antioxidants, flavanoids, and phytonutrients scavenges free radicals preventing them from attacking healthy cells as well repairing damaged cells.

The claims:
Comprehensive specifically designed to combat the stresses associated with the use of "pro anabolics"

Provides complete liver, prostate and heart protection and acts as a restorative as well

Formulated to synergistically stack with purus products halovar and recycle

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Current Rating: 8.8

Alpha Lipoic Acid (ALA)

Alpha-lipoic acid (ALA) is an antioxidant made by the body and is found in every cell, where it helps turn glucose into energy. Unlike other antioxidants, which work only in water (such as vitamin C) or fatty tissues (such as vitamin E), ALA is both fat and water soluble.

In the cells of the body, ALA is converted into dihydrolipoic acid. ALA is not the same as alpha linolenic acid, which is an omega-3 fatty acid that may help heart health.

ALA has been proposed as a treatment for alcohol-related liver disease, but so far there is no evidence that it works. ALA has been administered by IV along with silymarin (milk thistle) to treat people who have eaten the poisonous mushroom Amanita, which causes liver damage.

Beta-Sitosterol (PYGEUM AFRICANUM)

Beta-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a characteristic odor. They are hydrophobic and soluble in alcohols.

Numerous plants contain cholesterol-like compounds called sitosterols and their close relatives sitosterolins. A special mixture of these called beta-sitosterol is used for the treatment of benign prostatic hyperplasia (BPH).Beta-sitosterol joins saw palmetto , pygeum , nettle , and grass pollen as a moderately well-documented treatment for BPH.

Alone and in combination with similar phytosterols, Beta-Sitosterol reduces blood levels of cholesterol, and is sometimes used in treating hypercholesterolemia. Beta-Sitosterol inhibits cholesterol absorption in the intestine. When the sterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. Phytosterols and phytostanols both inhibit the uptake of dietary and biliary cholesterol, decreasing the levels of LDL and serum total cholesterol. Because the structure of Beta-Sitosterol is very similar to that of cholesterol, Beta-Sitosterol takes the place of dietary and biliary cholesterol in micelles produced in the intestinal lumen. This causes less cholesterol absorption in the body.

A review of the literature, published in 1999, found a total of four double-blind placebo-controlled studies on beta-sitosterol for BPH, enrolling a total of 519 men. 4-7 All but one of these studies found significant benefits in both perceived symptoms and objective measurements, such as urine flow rate.

The largest study followed 200 men with BPH for a period of 6 months. 8 After the trial was completed, many of the participants were followed for an additional year, during which the benefits continued. 9 Similar results were seen in a 6-month, double-blind trial of 177 individuals. 10

Beta-sitosterol binds to prostate tissue and affects the metabolism of prostaglandins, substances found in the body that affect pain and inflammation. 1 However, it is not clear whether this is the correct explanation for how beta-sitosterol might help in BPH.


Coenzyme Q10

Coenzyme Q10 (CoQ10) is a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS.

CoQ10 is involved in making an important molecule known as adenosine triphosphate (ATP). ATP serves as the cell's major energy source and drives a number of biological processes, including muscle contraction and the production of protein. CoQ10 also works as an antioxidant.

Clinical research suggests that using coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat heart disease, high blood pressure, high cholesterol, and diabetes.

Primary dietary sources of CoQ10 include oily fish, organ meats, and whole grains. Most individuals obtain sufficient amounts of CoQ10 through a balanced diet, but supplementation may be useful for individuals with particular health conditions or taking certain medications.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.

Quercetin

Quercetin (a flavonol) is a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods.

Several studies show quercetin may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin may have inhibitory properties against cancer, prostatitis, heart disease, cataracts, allergies/inflammations, and respiratory diseases, such as bronchitis and asthma. It has also been claimed that quercetin reduces blood pressure in hypertensive subjects. An in vitro study showed that quercetin and resveratrol combined inhibited production of fat cells.

Despite preliminary indications of possible medicinal effects, quercetin has neither been confirmed as a specific therapeutic for any condition nor has it been approved by any regulatory agency. A bioavailability study done on rats showed that ingested quercetin is extensively metabolized into non-active phenolic acids, with more than 96% of the ingested amount excreted within 72 hours, indicating actual physiological roles, if they exist, involve quercetin in only minute amounts.

Saw Palmetto (SERENOA REPENS)

Saw palmetto (Serenoa repens, Sabal serrulata) is used popularly in Europe for symptoms associated with benign prostatic hypertrophy (enlargement of the prostate). Although not considered standard of care in the United States, it is the most popular herbal treatment for this condition. Saw palmetto is often combined with nettle extract.

Multiple mechanisms of action have been proposed, and saw palmetto appears to possess 5-?-reductase inhibitory activity (thereby preventing the conversion of testosterone to dihydrotestosterone). Hormonal/estrogenic effects have also been reported, as well as direct inhibitory effects on androgen receptors and anti-inflammatory properties.