Mutate Information (Prohormones)

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Ingredients
Manufactured by:
Genetyx Labs

Supplement Facts
Serving Size: 1 Capsule
Servings per Container: 90
13-ethyl-3-methoxy-gona-2,5(10)-dien-17-one 20mg
4-Chloro-17a-Methyl-Androsta-1,4-diene-3,17-diol 15mg
17b-hydroxy-2a,17-dimethyl-5a-androstan-3-one azine 6mg
2a 17a dimethyl etiocholan 3 one 17b-ol 6mg

Also contains Milk Thistle, N-acetyl-L-cysteine for support

Other Ingredients: maltodextrin, magnesium stearate, silicon dioxide.

Directions: Take 1 capsule 2x per day evenly space. Don't exceed 2 servings in a 24 hour period. Don't take continuously for longer than 4 weeks.

BaaaaaaaaBAM! Stack up boys!

Lots of people like Megaplexx, and here's the replacement. You got 4, countem', 4 prohormone/designer steroids compounds, and they're methylated too.

The only one I've seen mixed results from here is the Dymethazine. Some folks like it, some folks don't.

If you've poked around ProhormoneDB and read my write-ups, you know I'm anti-stack. That said, the dosages here look pretty good. Now Im not in any way, shape or form going to stacj 4 methyls, but there are plenty of poeple out there who will.

The company is officially pushing this as a replacement for Megaplexx.

4 Ph's stacked:
13 ethyl blend with S-Drol, H-Drol, and DMZ.

This is pretty new stuff, so I'm not seeing logs/reviews out there. If you run across some, be a good community member, register at prohormoneDB, and add the links.

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13-ethyl-3-methoxy-gona-2,5(10)diene-17-one (Max LMG)

Trade names include Max LMG, Tren, Trena, AKA Methoxygonadiene

Common dosage: 60-120mg daily
Common cycle length: 4-6 weeks
Methylated: No
Half-Life:Long (48-72 hours)

Not a 17aa steroid so liver toxicity is not as harsh as with 17aa steorids, however the ethyl group on C-18 may make it slightly more toxic than a non-ethylated steroid (while increasing its oral bio-availability). Max LMG is progestin designed to give solid gains in muscle mass with low water retention. The progestational activity of methoxygonadiene (once it is converted to its active metabolites) is considered to be slightly stronger than nandrolone. This means muscle building with Max LMG in your cycle gives you higher quality hardening effects. Since it acts as anti-progesterone, there are decreased negative effects of extra estrogen and increased libido.

It is legal because it is a progestin, like trenbolone, nandrolone, methyltrienolone and Methyl-Dien. As a progestin, Max LMG is structurally related to the pill RU-486 and as such acts as an "anti-progesterone". This results in decreased estrogen-like effects and an increase in libido.

Research suggests that Max LMG has a half-life of about 6 hours, though it appears that it is closer to 10 hours based upon plasma levels maintained in test subjects. It is not a 17-alkylated analog and has a low potential for liver toxicity.

Most users report good results at a dosage of 75mg a day.

Some comments from users:

"As stated, appears to be an all out bulker. Great for size and strength, but notorious for bloat and the potential for gyno. I've also read that it kills libido pretty quickly. Some of the makers claimed that the libido would remain fine if one didn't use too large of daily doses though. I remember seeing people getting decent gains from 40mg - 50mg (depending on the product). It looks like most guys go up to 75mg though."

"Would be my favorite if it didn't make my nips start burning by the end of week two. Rapid weight gain on it plus the fact its not methyl are pluses. Just keep in mind i've seen many complain about it easily aggrevating gyno."

In the stomach acid, the C-3 methoxy group is rapidly cleaved off and the double bond on the A ring at C-2 is lost. At this point, a 3-oxo is formed and a metabolite known as 13b-ethyl-nor-androstenedione is created, which is chemically similar to norbolethone, and probably where this compound gets most of its effects.

13b-ethyl-nor-androstenedione is about equal to testosterone in anabolic potency, yet less androgenic. This would make this compound fairly light on the hairline with minimal chance of acne or other androgenic side-effects.

With low androgenic activity, this compound may negatively affect the libido and erectile function. The lack of androgenic potency and progestational effects make this compound likely to cause gyno symptoms. Users could stack this compound with testosterone or one of its non-aromatizing metabolites to preserve DHT levels and possibly prevent these side-effects.

Users experience rapid weight gain from this compound partly due to subcutaneous water retention from the progestational activity. Therefore the overall gains from this compound may lead to a bloated appearance. Because of the progestational effects, users should avoid stacking this compound with other gyno aggravating compounds. Max LMG can aromatize to estrogen in small amounts, however not to any significant degree, therefore an aromatase inhibitor would provide little protection against this compound's side-effects.

Max LMG immediately converts in the stomach into a 13b alkylated compound (13b ethyl nor androstenedione) and then makes it all the way to the liver because it is ethylated to survive first pass, and is converted into 13b ethyl nor testosterone, a steroid similar to norbolethone aka the clear.

17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine (Dymethazine)

Trade Name: Dymethazine

Dymethazine (aka mebolazine) was brought to market by iForce Nutrition in 2009, however, despite Dymethazine being 'legal' it was largely taken off the market due to recent FDA activities. Despite this, clones of the original Dymethazine have already been brought to the market. Dymethazine and DZine are interchangeable featuring the same compound (2,17-dimethyl-5-androstan-17-ol-3,3-one-azine)

Dymethazine is an azine, two superdrol molecules attached to each other by a nitrogen atom. Stomach acid separates the two superdrol molecules from each other, after which they make their way to the androgen receptors. Dymethazine is also known as mebalozine.

Dymethazine is nearly identical to Superdrol, except it's two (as opposed to one) superdrol molecules attached to each other. Your body's stomach acid separates these two molecules prior to absorption, so it becomes a single molecule with two potential pathways. Despite this difference, Superdrol remains the more powerful compound.

The one advantage Dymethazine has over Superdrol is the lower likelihood/greater managability of side effects. Dymethazine is an incredibly potent compound and carries the same risks as any other powerful anabolic steroid or pro-hormone.

In a study, patients were administered Dymethazine for 45+ days. Liver values did not change for 50% of patients, while the other 50% noticed only modest to moderate increases in liver values. So, while Dymethazine can increase liver values, it is not as harsh as the current strong methyls currently available.

Dymethazine features 0% ability to aromatize and expresses an extremely weak androgenic activity. This means Dymethazine will produce gain with little to no liver impact and will cause no estrogen related side effects.

2a-17a-di-methyl-etiocholan-3-one,17b-ol (Superdrol)

Yet another nomenclature for Superdrol.

2a,17a-di-methyl-etiocholan-3-one,17b-ol and 2a,17a-dimethyl-17b-hydroxy-5a-androstan-3-one are the same exact compounds written differently. They are both methylated at the 2a and 17a positions, both have a hydroxyl (alcohol, -OH) group at the 17b potion, and a ketone at position three. Just one attempts to use the term etiocholan, which isn't used too often.

A derivative of Drostanolon which is the 2-methylated form of DHT, so it has typically been used for reducing body-fat and water retention, while increasing muscle hardness and density. There should be no estrogen conversion with this compound, because it's 5a-reduced and A-ring alkylated on top of that. Also, the parent compound is used exclusively as an anti-neoplastic for metastatic breast cancer, so it's a strong anti-e with mild diuretic effects.

Has an extremely favorable Q (anabolic/androgenic) ratio. Q ratio = 20 (m-1-t is between 5-16, depending on assay). 20% as androgenic as 17a-MT oral (the reference standard); (m-1-t is 100-220% as androgenic as 17a-MT, for comparison). Superdrol is 400-800% as anabolic as the reference standard (17a-MT); (m-1-t is 910-1600% comparatively). The low androgenic profile of Superdrol will keep (androgenic) side-effects to a minimum.

Some users complain of delayed gyno up to 6 months after a good PCT. It's effective at 20mg, and usually provides very dry lean mass gains. Strength gains are moderate, but not usually maintainable post cycle. A very harsh compound, and should not be taken lightly. A good PCT and support supplement regime is essential.

4-chloro-17a-methyl-androst-1,4-diene-3-17b-diol (Halovar)

A clone of Halodrol (4-chloro-17a-methyl-androst-1, 4-diene-3b,17b-diol)

Halodrol is a 17aa steroid that converts to the steroid oral Turinabol after interaction with 3b-HSD at an estimated rate of about 5%. Because of this low conversion, doses must be higher than other 17aa pro-steroids. However, it is suspected that Halodrol has decent potency without conversion as good results are seen despite the relatively low conversion to Turinabol. Halodrol appears to be about as potent as testosterone, and significantly less androgenic.

Because of the 4-chloro group, halodrol has no progestational effects, it cannot interact with the aromatase enzyme, and it produces inactive 4-chloro-DHT metabolites. This makes androgenic side-effects such as hair loss, high blood pressure, acne and prostate enlargement less likely.

The lack of androgenic potency might be expected to create problems with gyno, however the low SHBG binding affinity has minimal interference with SHBG levels and/or freely circuiting estrogen and testosterone. It does not appear that halodrol has a significant gyno risk.

Because halodrol must be used at such a high dose to see noticeable effects, liver toxicity may become an issue. Therefore it is recommended to use a liver protecting supplement before and during halodrol cycles.

Gains from Halodrol generally take a few weeks to notice, but users can expect solid increases in strength, lean muscle mass, improved vascularity and minimal water retention. This allows some of the gains to be kept after the cycle if good diet and training are continued. Quick dramatic gains in size and strength are not generally noticed with Halodrol.

H-Drol is one of the most popular and proven compounds on the market and is considered good for beginners due to it's reputation for minimal side effects and dry gains that are relatively easy to maintain after the cycle is complete.

Magnesium Stearate

Magnesium stearate is often used as a diluent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets.

Magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, but not that it reduces the over-all bioavailability of those ingredients.

Maltodextrin

Maltodextrin is a polysaccharide that is used as a food additive. It is produced from starch by partial hydrolysis and is usually found as a creamy-white hygroscopic spraydried powder. Maltodextrin is easily digestible, being absorbed as rapidly as glucose, and might be either moderately sweet or almost flavorless. It is commonly used for the production of natural sodas and candy.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.

Silicon Dioxide (Silica)

The chemical compound silicon dioxide, also known as silica, is an oxide of silicon. Silica is most commonly found in nature as sand or quartz.

Silica is common additive in the production of foods, where it is used primarily as a flow agent in powdered foods, or to absorb water in hygroscopic applications. It is the primary component of diatomaceous earth which has many uses ranging from filtration to insect control. It is also the primary component of rice husk ash which is used, for example, in filtration and cement manufacturing.