Methyl 1-D Information (Test Boosters/Hormone Regulation)
LG Sciences (Legal Gear)
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving:
Metabolism Complex 261mg:
Ellagic Acid Standardized
Coleus Forskolin Standardized
Caprylate Acid (may contain: sodium caprylate, zinc caprylate, magnesium caprylate)
Milk Thistle (standardized)
Stinging Nettle Extract
Directions: Take 4-6 capsules per day in divided doses 35 minutes before meals. Use Methyl 1-D for up to 4 to 6 week cycles.
I was torn between listing this as a Prohormone (some of which we all know are simply designer steroids) and Testosterone Boosters. Utimately, I opted for Testosterone Booster, mainly because most reports on this product indicate it doesn't do much as far as promoting increases in lean body mass or losing fat.
Personally, I think it's being mismarketed and LG Science is using some fancy science-speak to disguise and confuse. All this is is DHEA and ATD (both of which are readily available as supplements) with a bunch of herbals thrown in. Read more anout them below.
Research seems conclusive that DHEA is pretty worthless for your average male looking to increase testosterone for the purpose of build mass. Sure, it does convert to testosterone (on the second conversion), but it can convert to other stuff as well. Maybe it helps old men with abnormally low testosterone to start, but for your average joe, it's probably not going to do anything.
The company write-up you see on the retail sites makes this sound like the greatest thing since Dianabol, including a recommendation for Post Cycle Therapy. I think that's misleading, especially to a younger crowd of lifters who might not be as thorough in their research as they should be. Although I've never used it, based on my research, I don't think I would.
Methyl 1-D Ingredients
1,4,6 etioallocholan-dione (ATD)Same thing as 1,4,6-androstatriene-3,17-dione.
ATD is an aromatase inhibitor (AI) and often praised for its estrogen control ability. By blocking the enzyme that converts testosterone to estrogen, AIs can prevent some of the androgenic side effects associated with prohormone and steroid use such as gyno and water retention.
It's been proven an effective AI in animal and cell culture studies, but there's little evidence or information on its effects in humans. AIs, especially prescription AIS such as anastrozole, have been proven effective, but the increases are within normal limits. AIs don't elevate natural testosterone to the levels seen with pro-hormones and steroids. Over-the-counter AIs were originally developed to help restore normal testosterone production after a prohormone/steroid cycle during the post cycle recovery phase, yet as stand-alone test boosters, they're not proven to be effective.
3-beta-hydroxyetioallocholan-5-ene-17-one (DHEA)3-beta-hydroxyetioallocholan-5-ene-17-one should actually be 3-beta-hydroxyetioallocholen-5-ene-17-one and is the compound nomenclature for DHEA (dehydroepiandrosterone). DHEA dhea is a a steroid hormone produced by the adrenal glands and a precursor to androstenedione. It can convert into the androgen testosterone, but it also can convert into estrone, and estradiol. It's too weak to really make a difference in absolute testosterone levels.
DHEA has therapeutic uses and is an unlikely candidate for abuse, as research has demonstrated that it's not much of a muscle-builder. Although DHEA can be converted to testosterone in the body, it's not a primary source of the hormone in men.
DHEA might fit the description of "the ONLY real PROHORMONE still available today," but will it give you "extreme gains in strength and size" or "skyrocketing testosterone levels" as suggested in ads for Methyl 1-D? Not likely. Even in large doses, these effects have never been demonstrated.
"The dietary supplements androstenedione, dehydroepiandrosterone, and androstenediol are precursors in the endogenous production of testosterone. The efficacy and safety of these prohormones are not well established but are promoted to have the same androgenic effects on building muscle mass and strength as anabolic-androgenic steroids. Studies have demonstrated repeatedly that acute and long-term administration of these oral testosterone precursors does not effectively increase serum testosterone levels and fails to produce any significant changes in lean body mass, muscle strength, or performance improvement compared with placebo." (Pediatr Clin North Am. 2007 Aug;54(4):787-96).
Caprylic Acid (Caprylate Acid)Caprylic acid is the common name for the eight-carbon saturated fatty acid known by the systematic name octanoic acid. It is found naturally in the milk of various mammals, and it is a minor constituent of coconut oil and palm kernel oil. It is an oily liquid that is minimally soluble in water with a slightly unpleasant rancid-like smell.
Caprylic acid is used in the treatment of some bacterial infections. Due to its relatively short chain length it has no difficulty in penetrating fatty cell wall membranes, hence its effectiveness in combating certain lipid-coated bacteria, such as Staphylococcus aureus and various species of Streptococcus.
Among the many natural cures for candida, caprylic acid is one of the most commonly cited. Candida albicans is yeast (or fungus) that normally inhabits our digestive system. In healthy people, candida does little harm because it's kept in check by beneficial microorganisms. These "good" bacteria can be easily destroyed by antibiotics, prescription medications, birth control pills, poor diet and daily stress, allowing Candida yeast to grow out of control and produce infections. Thought to affect more than 40 million Americans, Candida can cause uncomfortable symptoms such as vaginitis, weight retention, bowel disorders, ear and sinus irritation, intense itching, canker sores and ringworm.
Caprylic Acid is known to have anti-fungal as well as some anti-bacterial and anti-viral properties. One of the difficulties with caprylic acid is that, being a medium chain fatty acid, it is very easily digested and absorbed by the body. Thus, it often gets absorbed in the stomach and small intestines before it reaches the large intestines, where it it most needed.
Coleus ForskohliiPlectranthus barbatus, or more commonly known as Coleus forskohlii and Indian Coleus (Kikuyu: Maigoya), is a tropical perennial plant related to the typical coleus species. It is interesting from a scientific and medicinal standpoint because it produces forskolin.
Coleus is increasingly being used to assist weight loss by breaking down adipose tissue and preventing production of fatty tissue. In addition, coleus mildly stimulates the metabolism by increasing thyroid hormones and increasing the secretion of insulin. These therapeutic indications for coleus are due to its principal active compound, a diterpenoid called forskolin. This is the only plant-derived compound known to directly stimulate the enzyme adenlylate cyclase and, in turn, stimulate cellular cyclic AMP which boosts metabolism.
Increased cellular cyclic AMP reduces histamine, making coleus beneficial in the treatment of allergies. Coleus is also a bronchodilator with an anti-histamine action, making it useful in treating asthma. Conditions such as hypothyroidism, eczema, psoriasis are also improved by using coleus, largely due to its ability to increase cyclic AMP.
Indian and Chinese studies in the last two years have isolated a number of diterpenoids in the stem and leaves of coleus forskohlii with a focus on treatment of gastric cancer and preventing metastatic (secondary) cancers. These have been carried out on animal models with success.
Ellagic acidEllagic acid is a polyphenol antioxidant found in numerous fruits and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, wolfberry and other plant foods. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
Ellagic acid has antiproliferative and antioxidant properties in a number of in vitro and small-animal models. The antiproliferative properties of ellagic acid are due to its ability to directly inhibit the DNA binding of certain carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons. As with other polyphenol antioxidants, ellagic acid has a chemoprotective effect in cellular models by reducing oxidative stress. Though it is antagonistic with catechins, such as those found in tea.
These properties have generated interest in potential human health benefits from the consumption of ellagic acid. However, very little study of these proposed benefits has been reported as of 2010. A small randomized controlled trial involving 19 patients with carotid artery stenosis found that pomegranate juice, which is high in ellagic acid, appeared to reduce blood pressure and carotid artery wall thickness.
A 2005 controlled study of 48 patients undergoing chemotherapy for prostate cancer found that ellagic acid supplementation reduced the rate of chemotherapy-associated neutropenia. Ellagic acid supplementation did not improve overall or progression-free survival of patients with prostate cancer in this trial.
Despite the very preliminary state of evidence supporting health benefits in humans, ellagic acid has been marketed as a dietary supplement with a range of claimed benefits against cancer, heart disease, and other medical problems. Ellagic acid has been identified by the U.S. Food and Drug Administration as a "Fake Cancer Cure Consumers Should Avoid".
LuteolinLuteolin is a one of the citrus bioflavonoids and, like most flavonoids, has antioxidant, anti-inflammatory, and anti-tumor properties. Preliminary research has revealed evidence that it acts as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator. Basic research results indicate luteolin as an anti-inflammatory agent with other potential effects on septic shock. Luteolin is found in high amounts in parsley, thyme, peppermint, basil herb, celery and artichoke.
Luteolin exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. It also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells.
University of Illinois researchers report lutelin can disrupt a component of the inflammatory response in the brain. Research found that luteolin inhibits a key pathway in the inflammatory response of microglia--brain cells key to the body's immune defense. Microglial cells exposed to luteolin show a significantly diminished inflammatory response. Luteolin reduces production of interleukin-6 in the inflammatory pathway by as much as 90 percent.
Milk Thistle (SILYMARIN)The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.
The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.
Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.
Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".
A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.
A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective, while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.
Beside benefits for liver disease, other unproven treatment claims include:
Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage
Lowering cholesterol levels
Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
Reducing the growth of cancer cells in breast, cervical, and prostate cancers.
Used in many products claiming to reduce the effects of a hangover
Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.
Reducing liver damaging effects of chemotherapeutic drugs
Clinical study has shown that liver function tests can be improved in active hepatitis patients.
PiperinePiperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.
Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.
Piperine may also have some harmful side effects. Preliminary evidence shows it may be toxic in some circumstances, and may even interfere with reproductive processes, including negative effects on sperm. Piperine at doses higher than 15 mg daily may affect the metabolism of a wide range of drugs. Even lower doses may affect the bodys metabolism of some drugs.
Piperine may also form cancer-causing substances when eaten with nitrates. Experts suggest that people who take piperine supplements should be careful when also eating food that contains nitrates as a preservative.
Not enough human studies have been done to determine the side effects of chronic supplementation with piperine. For the time being, it is a good idea to take 2 days off a week, and one full week off each month from the use of a piperine supplement. It is quite likely that the small amounts of piperine could provide health benefits while larger amounts could be toxic or damaging to the liver or other organs.
Stinging Nettle (Urtica dioica)Stinging nettle or common nettle, Urtica dioica, is a herbaceous perennial flowering plant, native to Europe, Asia, northern Africa, and North America, and is the best-known member of the nettle genus Urtica. The plant has many hollow stinging hairs called trichomes on its leaves and stems, which act like hypodermic needles that inject histamine and other chemicals that produce a stinging sensation when contacted by humans and other animals. The plant has a long history of use as a medicine and as a food source. In medieval Europe, it was used as a diuretic (to rid the body of excess water) and to treat joint pain.
Stinging nettle has been used for hundreds of years to treat painful muscles and joints, eczema, arthritis, gout, and anemia. Today, many people use it to treat urinary problems during the early stages of benign prostatic hyperplasia or BPH, for urinary tract infections, for hay fever (allergic rhinitis), or in compresses or creams for treating joint pain, sprains and strains, tendonitis, and insect bites.
Studies in people suggest that stinging nettle, in combination with other herbs (especially saw palmetto), may be effective at relieving symptoms such as reduced urinary flow, incomplete emptying of the bladder, post urination dripping, and the constant urge to urinate associated with an enlarged prostate. Laboratory studies have shown stinging nettle to be comparable to finasteride (a medication commonly prescribed for BPH) in slowing the growth of certain prostate cells. However, unlike finasteride, the herb does not decrease prostate size.
The leaves and stems of nettle have been used historically to treat arthritis and for sore muscles. Studies have been small and not conclusive, but do suggest some people find relief from joint pain by applying nettle leaf topically to the painful area.
One preliminary human study suggested that nettle capsules helped reduce sneezing and itching in people with hay fever. Researchers think that may be due to nettle's ability to reduce the amount of histamine the body produces in response to an allergen.
Some preliminary animal studies indicate that nettle may lower blood sugar and blood pressure, but there is not enough evidence to say whether this is also true in humans.
Zinc AspartateZinc L-aspartate, often simply called zinc aspartate, is a chelated mineral supplement and an important naturally occurring bioavailable delivery form of zinc. Zinc aspartate is a salt of zinc with the amino acid aspartic acid.
Zinc is an essential trace element, necessary for plants, animals, and microorganisms. Zinc is found in nearly 100 specific enzymes (other sources say 300), serves as structural ions in transcription factors and is stored and transferred in metallothioneins. It is "typically the second most abundant transition metal in organisms" after iron and it is the only metal which appears in all enzyme classes.
In humans, zinc interacts with "a wide range of organic ligands" and has roles in the metabolism of RNA and DNA, signal transduction, and gene expression. It also regulates apoptosis.