Metha-drol Extreme Information (Prohormones)

Metha-drol Extreme by


Ratings
Ingredients
Manufactured by:
IronMag Labs

Serving Size: 1 Capsule
Servings per Container: 60 capsules

Supplement Facts:
2a-17a-dimethyl-17a-hydroxy, 5a etiocholan 3-one - 10 mg (Superdrol)
2a-17a-dimethyl-5a-androstan, 17b-ol 3, 3-azine - 15 mg (Dimethazine)
13-ethyle-3-methoxy-gona-2,5 (10)-dien-17-one - 15 mg (Decadrol)

Proprietary Blend 105.5mg:
6,7-dihydroxybergamottin 25 mg
Niacinamide 50 mg
Pyridoxine HCl 25 mg
Piperine 95% 5 mg
Cyanocobalamin 500 mcg

Bottle recommended dosage: As a dietary supplement, take 1 capsule in the AM and 1 capsule after a PM workout or prior to bed. Do NOT exceed more than 2 capsules in a 24 hour period.

Here's the warning from the company:
This product should only be used by healthy adults at least 21 years old. Do not exceed the recommended dose or duration of 4 weeks. Do not use if you are at risk of, or being treated for diabetes, liver problems or high blood pressure. Do not drink alcohol while using this product, and increase daily water intake. Advanced Cycle Support Rx should always be used along with Metha-Drol Extreme. Always Consult your health care professional before using any dietary supplements.

I'm not sure why the officail write up under ingredients list Decadrol by the Max LMG compound. When I looked up Decarol, the Google told me it was a prohormone made by ProCycle Labs. Intersting to note the active ingredients of Decadrol:

2-ene-17a,methy-etiocholan,-2-ene-17b,ol - 10 mg
2a, 17a-dimenthy-5a,-androst,-3-one-17b-ol - 10 mg
13-ethyl-3-methoxy-gona-2,5,(10)-dien-17-one - 25 mg

Almost the same as for Metha-drol Extreme.

In any case, from the research I've done, 13-ethyl-3-methoxy-gona-2,5,(10)-dien-17-one is Max LMG, not "Decadrol".

As always, it's important to look at the dailt dosage for each of the compounds.

Superdrol: 20mg
Dymethazine: 30mg
Max LMG: 30mg

Superdrol looks good - many users report great results running 20mg of Superdrol as a standalone.

For the Dymethazine, the recommended standalone dosage is 30mg up to 45mg for experienced users, so this one tracks OK.

Standalone dosage for Max LMG is from 60 - 120mg, so the 30mg here could be a little light. But considering that it's stacked with two others already at standalones dosages, maybe that's intentional.

All three of these compounds have the reputation for being effective, although from what I've read Dymethazine can be hit or miss for some folks.

I do like how IronMag Labs recommends a max of 4 weeks on this. I've seen some companies telling you to run their stacks for as long as 8 weeks.

This is a strong combination of compounds - make sure you prep for it, take your support supplements, and have a good perscription strength PCT in place.



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13-ethyl-3-methoxy-gona-2,5(10)diene-17-one (Max LMG)

Trade names include Max LMG, Tren, Trena, AKA Methoxygonadiene

Common dosage: 60-120mg daily
Common cycle length: 4-6 weeks
Methylated: No
Half-Life:Long (48-72 hours)

Not a 17aa steroid so liver toxicity is not as harsh as with 17aa steorids, however the ethyl group on C-18 may make it slightly more toxic than a non-ethylated steroid (while increasing its oral bio-availability). Max LMG is progestin designed to give solid gains in muscle mass with low water retention. The progestational activity of methoxygonadiene (once it is converted to its active metabolites) is considered to be slightly stronger than nandrolone. This means muscle building with Max LMG in your cycle gives you higher quality hardening effects. Since it acts as anti-progesterone, there are decreased negative effects of extra estrogen and increased libido.

It is legal because it is a progestin, like trenbolone, nandrolone, methyltrienolone and Methyl-Dien. As a progestin, Max LMG is structurally related to the pill RU-486 and as such acts as an "anti-progesterone". This results in decreased estrogen-like effects and an increase in libido.

Research suggests that Max LMG has a half-life of about 6 hours, though it appears that it is closer to 10 hours based upon plasma levels maintained in test subjects. It is not a 17-alkylated analog and has a low potential for liver toxicity.

Most users report good results at a dosage of 75mg a day.

Some comments from users:

"As stated, appears to be an all out bulker. Great for size and strength, but notorious for bloat and the potential for gyno. I've also read that it kills libido pretty quickly. Some of the makers claimed that the libido would remain fine if one didn't use too large of daily doses though. I remember seeing people getting decent gains from 40mg - 50mg (depending on the product). It looks like most guys go up to 75mg though."

"Would be my favorite if it didn't make my nips start burning by the end of week two. Rapid weight gain on it plus the fact its not methyl are pluses. Just keep in mind i've seen many complain about it easily aggrevating gyno."

In the stomach acid, the C-3 methoxy group is rapidly cleaved off and the double bond on the A ring at C-2 is lost. At this point, a 3-oxo is formed and a metabolite known as 13b-ethyl-nor-androstenedione is created, which is chemically similar to norbolethone, and probably where this compound gets most of its effects.

13b-ethyl-nor-androstenedione is about equal to testosterone in anabolic potency, yet less androgenic. This would make this compound fairly light on the hairline with minimal chance of acne or other androgenic side-effects.

With low androgenic activity, this compound may negatively affect the libido and erectile function. The lack of androgenic potency and progestational effects make this compound likely to cause gyno symptoms. Users could stack this compound with testosterone or one of its non-aromatizing metabolites to preserve DHT levels and possibly prevent these side-effects.

Users experience rapid weight gain from this compound partly due to subcutaneous water retention from the progestational activity. Therefore the overall gains from this compound may lead to a bloated appearance. Because of the progestational effects, users should avoid stacking this compound with other gyno aggravating compounds. Max LMG can aromatize to estrogen in small amounts, however not to any significant degree, therefore an aromatase inhibitor would provide little protection against this compound's side-effects.

Max LMG immediately converts in the stomach into a 13b alkylated compound (13b ethyl nor androstenedione) and then makes it all the way to the liver because it is ethylated to survive first pass, and is converted into 13b ethyl nor testosterone, a steroid similar to norbolethone aka the clear.

2a,17a-dimethyl-17a-hydroxy,5a-etiocholan-3-one (Superdrol)

Seems to be yet another chemical nomenclature for Superdrol:

2a,17a-dimethyl-5a-androst-3-one-17b-ol (Superdrol)
2a,17a-dimethyl-17b-Hydroxy-5a-androstan-3-one
(Superdrol)


Superdrol is a powerful anabolic designer steroid brought to market in 2005, however due pressure by the FDA, the original Superdrol was pulled and is no longer available. Like many other compounds, it has been made available again through the production of clones.

2a,17a-dimethyl-5a-androst-17b-ol-3,3-azine

An alternate nomenclature for Dimethazine, the other one being D-Zine (17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine).

Dymethazine (aka mebolazine) was brought to market by iForce Nutrition in 2009, however, despite Dymethazine being 'legal' it was largely taken off the market due to recent FDA activities. Despite this, clones of the original Dymethazine have already been brought to the market. Dymethazine and DZine are interchangeable.

Dymethazine is essentially two superdrol molecules attached by a nitrogen atom. Stomach acid breaks the two superdrol molecules apart. Dymethazine is also known as mebalozine. Dymethazine is very close to Superdrol, except it's two superdrol molecules attached to each other. Despite this, Superdrol remains the more powerful compound.

One advantage Dymethazine has over Superdrol is the lower likelihood/greater managability of side effects. Dymethazine is an incredibly potent compound and carries the same risks as any other powerful anabolic steroid or pro-hormone.

If you were to believe manufacture claims, then this is the end all, be all of prohormones/designer steroids: "A never before seen molecular structure enables Dymethazine to harness one of the strongest anabolic:androgenic ratios ever seen. Featuring a greater myotropic effect than Winstrol, Oxymethalone, Testosterone Prop, and Methyl-Test, Dymethazine has been shown to not only be the strongest PH ever made, but also one of the strongest compounds ever produced."

Despite this extravagent claim, user reviews seem to be mixed....

6,7-dihydroxybergamottin (DHB)

Along with the chemical Bergamottin, it is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.

Chemically, bergamottin and 6,7-dihydroxybergamottin are linear furanocoumarins functionalized with side chains derived from geraniol. They are inhibitors of some isoforms of the cytochrome P450 enzyme, particularly CYP3A4. This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream.

Normally, the grapefruit juice effect is considered to be a negative interaction, and patients are often warned not to consume grapefruit or its juice when taking medication. However, some current research is focused on the potential benefits of cytochrome P450 inhibition. Bergamottin, dihydroxybergamottin, or synthetic analogs may be developed as drugs that are targeted to increase the oral bioavailability of other drugs.

Cyanocobalamin

Cyanocobalamin is a common vitamer of the vitamin B12 family. A form of vitamin B12 called hydroxocobalamin is produced by bacteria, and then changed to cyanocobalamin in the process of being purified in activated charcoal columns after being separated from the bacterial cultures. Cyanocobalamin is the vitamin B12 that is found in most meat and meat products, and in most vitamin B12 supplements.

Cyanocobalamin usually does not even occur in nature, and is not one of the forms of the vitamin that are directly used in the body. However, animals and humans can convert cyanocobalamin to active (cofactor) forms of the vitamin.

Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis. Sources include organ meats, meat, fish, eggs, milk and cheese. Vitamin B12 is not found in vegetables. The liver is the main storage site of vitamin B12. The human body stores about 4mcg of Vitamin B12 (2 in the liver and 2 elsewhere). These stores are enough to last for one to three years.

RDA is very small, being just 1mcg daily for adults and as little as .2mcg for children.

Niacinamide

Vitamin B3 is made up of niacin (nicotinic acid) and its amide, niacinamide, and can be found in yeast, meat, fish, milk, eggs, green vegetables, and cereal grains. Dietary tryptophan is also converted to niacin in the body. Vitamin B3 is often found in combination with other B vitamins including thiamine, riboflavin, pantothenic acid, pyridoxine, cyanocobalamin, and folic acid.

There's been specualtion that Niacinamide has positive effect on the HDL/choelsterol ratio, however, research indicates it is Niacine, not Niacinamide, that affects cholesterol levels.

Niacin decreases the rate of hepatic synthesis of very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) while raising high-density lipoprotein. This has led to a lowering of serum cholesterol by 10 to 15% and triglycerides by 20 to 30%. Niacinamide is not effective in lowering serum cholesterol.

High doses of Niacin can cause an uncomfortable flushing effect where the skin of the upper body reddens and become itchy due to histamine release. Tolerance after a few weeks of treatment usually develops and the flushin effect desreases.

Niacinamide is often sold in supplement form as no-flush Niacin, but it doesn't have the same positive lipid effects.

Piperine

Piperine is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.

Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. In animal studies, piperine also inhibited other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds and alter the effectiveness of some medications.

Piperine may also have some harmful side effects. Preliminary evidence shows it may be toxic in some circumstances, and may even interfere with reproductive processes, including negative effects on sperm. Piperine at doses higher than 15 mg daily may affect the metabolism of a wide range of drugs. Even lower doses may affect the bodys metabolism of some drugs.

Piperine may also form cancer-causing substances when eaten with nitrates. Experts suggest that people who take piperine supplements should be careful when also eating food that contains nitrates as a preservative.

Not enough human studies have been done to determine the side effects of chronic supplementation with piperine. For the time being, it is a good idea to take 2 days off a week, and one full week off each month from the use of a piperine supplement. It is quite likely that the small amounts of piperine could provide health benefits while larger amounts could be toxic or damaging to the liver or other organs.

Vitamin B-6

The primary role of vitamin B6 is to act as a coenzyme to many other enzymes in the body that are involved predominantly in metabolism. This role is performed by the active form, pyridoxal phosphate. This active form is converted from the two other natural forms founds in food: pyridoxal, pyridoxine and pyridoxamine.

Vitamin B6 is involved in the following metabolic processes:

amino acid, glucose and lipid metabolism

neurotransmitter synthesis

histamine synthesis

hemoglobin synthesis and function

gene expression

Amino acid metabolism

Pyridoxal phosphate is involved in almost all amino acid metabolism, from synthesis to breakdown.

Neurotransmitter synthesis

Pyridoxal phosphate-dependent enzymes play a role in the biosynthesis of four important neurotransmitters: serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid. Serine racemase, which synthesizes the neuromodulator D-serine, is also a pyridoxal phosphate-dependent enzyme.

Histamine synthesis

Pyridoxal phosphate is involved in the metabolism of histamine.

Hemoglobin synthesis and function

Pyridoxal phosphate aids in the synthesis of heme and can also bind to two sites on hemoglobin to enhance the oxygen binding of hemoglobin.

Gene expression

It transforms homocysteine into cistation then into cysteine. Pyridoxal phosphate has been implicated in increasing or decreasing the expression of certain genes. Increased intracellular levels of the vitamin will lead to a decrease in the transcription of glucocorticoid hormones. Also, vitamin B6 deficiency will lead to the increased expression of albumin mRNA. Also, pyridoxal phosphate will influence gene expression of glycoprotein IIb by interacting with various transcription factors. The result is inhibition of platelet aggregation.