Mammoth DNA Information (Prohormones)

Mammoth DNA by


Ratings
Ingredients
Manufactured by:
Xcel Sports Nutrition

Serving Size: 1 capsule
Servings Per Container: 60

Ingredients:
17a-methyl-1,4-androstene-3b 17b-diol (M1, 4ADD) 25mg
Estra-4 9 11-triene-3 17-dione (Trenavar) 15mg
2 3a-epithio-17a-methyletioallo cholan-17b-ol (Epistane) 40mg
6-chloro-androst-4-ene-3-one-17b-ol (Hexadrone) 12.5mg
2-cyano-17a-methyl-17b-acetoxy-5a-androst-2-ene (Cyanostane) 15mg
19-Norandrostenediol (Bolandiol) 35mg
l-3 4-dihydroxyphenylalanine (l-DOPA) 150mg
6-bromoandrostenedione 50mg
5a-hydroxy laxogenin 75mg
Carbopol 25mg
Milk Thistle (80% extract) 100mg
NAC (N-Acetyl-L-cysteine) 100mg
Long Jack (Tongkat Ali) 100mg

Other Ingredients: Gelatin (Capsules) and Magnesium Sterate

Suggested Use:
1 capsule, two times per day. This product may be taken in a 4 week cycle. This intense muscle building stack is intended for use by hardcore athletes who are trying to gain extreme size and strength.

Wow! This one took us a while to type up.

It appears that Mammoth DNA is one of the most powerful and effective pro hormone stacks on the market today - so it is not to be taken lightly, and certainly not for beginners.

With the exception of the 19-norandrostenediol, which was shown in clinical test not to have much effect on muscle mass or conversion (See pubmed publication: http://www.ncbi.nlm.nih.gov/pubmed/12297208), this product definitely packs a punch.

Xcel has crafted the art of placing carbopol in most, if not all of their products, so it's possible that the time-release agent slows down the absorption of all these compounds, and won't tax the liver as heavily.

Although liver support compounds are present with Milk Thistle, NAC, and Long Jack, it's still probably a good idea to continue take with a cycle support, and always finish with a proper PCT - in this case, a step up with a SERM might prove well.


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17a-methyl-1,4-androstadiene-3,17diol (M1,4ADD)

M1,4ADD is a prohormone of Dianabol, but is similar in structure to and said to act more like boldenone. When taken orally, 17a-methyl-1,4-androstadiene-3,17diol (M-1,4ADD) is converted by the enzyme 3HSD into dihydroboldenone. Recommended dosages are 30-90mg daily with cycles averaging 4-5 weeks in length. M1,4ADD isn?t recommended for first time pro-hormone and steroid users.

M1,4ADD has some conversion (around 15%) to Dianabol (methandrostenolone). It's been reported that despite conversion to Dianabol, the on-cycle feeling and results more closely resemble Boldione (Bold/1,4AD).

M1,4ADD is a wet (aromatizes) compound. Users can expect some estrogen related sides such as water retention, bloating and irritation or reappearance of existing gyno. It is common to use an AI to suppress estrogen while on cycle.

19-norandrostenediol (Bolandiol)

A synthetic steroid, Bolandiol comes from the 19-nor family which was designed to convert to 1-test, however, most forms are found to only convert to nor-test.

It is a potential metabolic precursor to nandrolone, and is also found on the World Doping Agency's banned list.

In 4, and 8-week clinical tests, subjects showed little to no gains, alterations, or changes in mood or body, and so it appears that low doses will do little for increased muscle gains.

As with most chemical compounds, the structures may vary from time to time, and appear as follows:

estr-4-ene-3β,17β-diol
19-Nor-4-androstene-3β,17β-diol
(3β,17β)-Dihydroxyestr-4-ene
Estr-4-ene-3β,17β-diol

2a,3a-epithio-17a-methyl-5a-androstan-17b-ol (Havoc/Epistane)

Also written as: 2a,3a-epithio-17a-methyl-17b-hydroxy-5a-adrostan

Trade names include Havoc/Epistane
Common Dosages: 30mg to 40mg daily
Common Cycle Length: 4-5 Weeks
Methylated: Yes
Half-Life: Average (6-8 hours)

A designer steroid and legal alternative to anabolic and androgenic steroids.

Epistane is a methylated version of the controlled substance Epitiostanol (2,3-Epithio-5-androstan-17-ol), created in the 1960's and used as a treatment for breast cancer. Chemists added a methyl group to the compound to create the product known as Epistane. Epistane is a sulfur containing steroid which is known to have strong and long lasting anti-estrogenic activity as well as weak androgenic and mytropic activities.

Since it is anti-estrogenic, you can expect very dry gains from this compound. Epistane has low androgenic to anabolic activity, meaning it is much more anabolic then androgenic. Even though users will see dry gains on Epistane it does not mean that it would be any insufficient for a bulking cycle.

Side effects are typically minimal to non existent.

2-cyano-17a-methyl-17b-acetoxy-5a-androst-2-ene (Cyanostane)

Another nomenclature used for the Cynostane compound.

2-cyano-17a-methyl-17b-hydroxy-androst-3-one (Cynostane)

Has a methyl group and hydroxyl group off of the 17th carbon. A methyl group has single bonds from a carbon to 3 hydrogens leaving the 4th bond open to bond to whatever, in this case the 17th carbon.. A hydroxyl group has a oxygen single bond to a hydrogen and another single bond to whatever, which in this case is the 17th carbon. Has a 2 and 3, both connect to the 17th carbon where the R is on the pictures on the links.

2-cyano-17a-methyl-17b-acetoxy-5a-androst-2-ene (Cynostane)

Has the same methyl group at the 17th position but also has a acetoxy group. A acetoxy group has an oxygen single bond to a carbon, off of this carbon is a double bond to an oxygen and also has a methyl group off of this carbon. The oxygen with the single bond to carbon is left with one bond free, it is here that bonds to the 17th carbon. Has a 1 and 2, both connect to the 17th carbon where the R is on the pictures in the links.

Cynostane features an alteration of the superdrol compound, with a cyano bond instead of the 2a methyl superdrol bond.

Cynostane is an extremely anabolic compound with remarkably low androgenic action, making it similar to Oxandrolone or Methenolone (primobolan). It's non-aromatizing meaning it won't produce estrogen mediated side effects and its high degree of anabolic action makes it a good choice for athletes wanting to lose bodyfat while maintaining, or increasing, muscle mass.

Blood work shows Cynostane has a less detrimental effect on blood lipids, and liver values than Superdrol. The combination of low androgenic action, lack of aromatization to estrogen, and low level of general health effects, makes cynostane an intriguing compound.

Its not going to be as powerful as superdrol in the strength department but it will be great for size and some good strength to. At the same time it is also not nearly as liver or lipid toxic ether.

This compound definitely appears to have oral activity, and very potent activity at that. It has the highest Q ratio, 20. That is the same Q ratio as superdrol, except this compound appears to be twice as anabolic as superdrol. I would expect dry gains, more similar to oxandrolone (anavar).

On the FDA ban list, so get it while you can!

5a-Hydroxy Laxogenin

5a-Hydroxy Laxogenin was discovered in 1996 and shown to have an anabolic/androgenic ratio similar Anavar, but without the side effects of liver toxicity or testing positive for steroidal therapy. Athletes claim to have seen strength increases in 3-5 days, and muscle mass increases in 3-4 weeks.
AKA Laxogenin

This ompound has shown up as a standalone in Anabolica and Zoe's Ecdysterone.

5a-hydroxy-laxogenin is a steroidal sapinogen, although whether or not it is the desired laxinogen is a mystery since no lab standard for it is available, nor was it referenced within the GCMS library.

Marketing claims for this compund say it is the only product ever designed to increase mass and strength without steroidal influence and that it doesn't test positive for steroids.

Tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.

It's also been shown to balance cortisol on calorie restricted diets, helps control glucose and increases thyroid function.

Drips and Drabs pulled from the Internets....

"Laxogenin does indeed have some pretty profound anti-inflammatory effects. In addition to being able to be synthesized from Diosgenin, it is a component of smilax sieboldii."

"Laxogenin is a steroidal sapogenin isolated from Smilax sieboldi. As a spirostanic analogue of the brassinosteroid - teasterone, Laxogenin is noted for it's growth promoting activity [in plants]. It has also been demonstrated to aquire [cytotoxic] properties however, to what degree, I am not sure. In contrast, Laxogenin was demonstrated to aquire antitumor-promoting activity in a two-stage lung carcinogenesis experiment."

"The best (published) study can be found in the journal Phytochemistry, 1971, vol. 10, pp 1339-1346. Again in 1989, same journal vol. 28, no. 9 pp 2509-2511 (laxogenin acetate). There is reference going back to 1965 in Chem. Pharm. Bull. 13(5), pp. 545-550 (laxogenin).

It was Syrov's paper of 1976 though, appearing in Farmakol, Toksikol that really sparked my interest. The paper is entitled, "An Experimental Study on the Anabolic Activities of 6-keto Derivatives of some natural sapogenins".

It details the 4 sapogenins (referred to as compounds 1-4 in the Soviet Union) and gives source material, results of the classic steroid model (levator ani studies) and mentions other clues critical to their use. Most of these compounds can be derived from Diosgenin (so can testosterone).

Laxogenin appears closest to Compound 2, the most desirable of these. Thermo includes it as 25R in their formulation and I very much wish it were available as a standalone. I can tell you from experience that when you get the right Laxogenin, it for sure delivers on the recovery, anti-inflammatory etc. side of things and is a superb regenerative agent.

NoHype, I would be most interested in your opinions in the event you do a deeper dive as I believe the compound holds great promise."

6-Bromoandrostenedione

I've been confusing myself again.

There's the compound 6-Bromodione which binds to the aromatase enzyme making it unable to convert androgens to estrogen.

6-alpha-Bromodione is a fast acting competitive inhibitor of the aromatase enzyme. It works by binding to the aromatase enzyme to prevent it from aromatizing androgens. This is not a permanent binding and later acts to normalize aromatase (and thus estrogen levels) as hormone production returns to normal. It specifically targets aromatase and does not act as a central anti-androgen like some other post cycle products can. This means that your libido and mood will not be negatively affected.

6-beta-Bromodione works in a similar way but has an irreversible and permanent effect. This works well to mediate the excess aromatase that was produced while on cycle, while the alpha isomer works to normalize the natural levels. The goal is again to transition into normal production levels for all hormones affected by the anabolic cycle.

I found "6-bromoandrostenedione vs. 6 Bromodione" and says: "They are the same thing; I think it also goes by "6-bromolane. I would imagine that products containing 6-bromodione would be a mixture of alpha and beta, given the expense associated with separation. Also, 6-alpha-bromodione should convert into 6-alpha-bromo-testosterone, which should be a relatively potent anabolic steroid. So, if taken for PCT, it could actually be suppressive (like epistane, which is both an AI and suppressive steroid). Actually, I bet 6-alpha-bromodione would make a decent PH.

I think 4-HO-androstenedione has been researched more, but both could probably lower androstenedione production."

6-chloro-androst-4-ene-3-one-17b-ol (Hexadrone)

I'm afraid I'm not finding a lot of information on this compound, and this write up is composed of bits and pieces from various boards as posted by people a lot smarter then me (hi HenryV and Patrick Arnold!).

Now here's the PR write up from Shredded Labs for their Hexadrone product; please note that on the bottle the compound is listed as 6-chloro-androst-4-ene-3-one-17b-ol whereas in the write up it's written as 6a-chloro-androst-4-ene-3-one-17b-ol. You'll see why this matters later.

Here's the PR:

6a-Chloro-androst-4-en-17b-ol-3-one represents the next generation of legal androgens: Extremely effective, dry, and non-methylated, it stacks well with everything, and is more than adequate for solo runs.

Powerful anabolic, rated at 300: (anabolic:androgenic) vs. testosterone.

Cannot convert to estrogen; immune to the effects of aromatase.

Intrinsically active compound with no conversion required.

Non-methylated, yet resistant to some aspects of CYP-mediated metabolism due to the Chloro group at C6.

In terms of results, this 6-chlorinated compound is equal to harsher androgens such as M1, 4ADD and Halodrol. In terms of toxicity, this compound cannot even be compared to them. It's much safer and much milder.

Unfortunately we know Press Releases aren't always 100% accurate. Here are some bits and pieces for you:


From a Shredded Labs Rep (sound surprisingly straightforward):
...these claims of SD (Superdrol) gains or that its a new tren are ridiculous. I PERSONALLY feel that this compound will feel like a hybrid between Halo/Epi/Boldione. It does have AI properties and cannot convert to Estrogen like Epi. It is a powerful yet non-methylated compound like Boldione which is mild on the body and stacks well with methylated and other non-methylated compounds as well as being very efficient when used solo, and I believe that the results when ran solo will be comparable to similar dosages of Halo. It is not Superdrol and will not give you gains of 20lbs from a 4 week cycle, but it will also not wreak the havoc on your body or come with the sides of SD. It is not a progestin like Tren, it should not cause any of the "deca-dick" or "trensomnia" sides of progestins, but it will have similar recomposition potential.... Dosing should be about 100mg daily split evenly between the day.

onyop888 from ProhormoneForum.com:
From what I can gather it is supposed to be similar to a non-methylated halodrol.

HenryV from ProhormoneForum.com:
They don't indicate the orientation of the 6-chloro. The 6a-isomer (Vida S-29) is much stronger than the 6b (S-71). It is a non-methyl.

Patrick Arnoild on ProhormoneForum.com in response to it being viable as a steroid similar to hdrol:
probably not as an oral. hdrol is methylated

When I search for Hexadrone there's even less info. Shredded Labs seems to be a real company, but I didn't find listing for Hexadrone on their site (although they seeem to have plenty of other goodies....)

Carbopol

Carbopol is a registered trademark of The Lubrizol Corporation for a family of polymers used as thickeners, suspending agents and stabilizers.

Carbopol is used as a thickening agent in lotions, creams and gels. It is also used to stabilize, suspend, and control the release of pharmaceutical products (time release).

Different varieties produce varying viscosities, but most are used below 1% concentration. The crosslinked polymers are not actually water soluble, but swell into hydrated spheres that are the source of it's thickening action.

Estra-4,9,11-triene-3,17-dione (Trenavar)

Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.

From HenryV:

Function:

This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.

Structure:

This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.

Effects:

Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.

Side Effects:

Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.

Metabolism and Bioavailability:

The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes [1], and also because trenbolone is an antagonist of the glucocorticoid receptor [2]. The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific [3]. Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?

The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats [4], and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.


Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<

Long Jack (Eurycoma Longifolia, Tongkat Ali, Pasak Bumi)

Long Jack (Eurycoma longifolia - commonly called tongkat ali or pasak bumi) is a flowering plant in the family Simaroubaceae, native to Indonesia, Malaysia, and, to a lesser extent, Thailand, Vietnam, and Laos.

Even though there are other legitimate medical areas of interest in Eurycoma longifolia, most Southeast Asians consume it for the plant's impact on sexual conduct. Already in 2001, Malaysian scientific researchers opened their peer-reviewed, Medline-archived report on Eurycoma longifolia's effect on lab rats with the statement "that Eurycoma longifolia Jack commonly known as Tongkat Ali has gained notoriety as a symbol of man's ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities."

Some scientific studies found that it enhances sexual characteristics and performance in rodents. Other laboratory animal tests have produced positive indications, with one extract having been observed to increase sexual activity in mature rats, including arousal, sniffing, and mounting behavior. In an experiment conducted on male rats, it was found that eurycoma longifolia increases sperm count. The authors also reported that the plasma testosterone level of Eurycoma longifolia extract treated rats "was significantly increased when compared with that of the control and infertile animals."

Another group of scientists confirmed that Eurycoma longifolia has the capacity to "reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis." One Medline-indexed journal article cited as result that Eurycoma longifalia had an effect similar to testosterone replacement therapy in counteracting ostereoposis.

In a placebo-controlled human study with healthy young men in a weight-training program, it was found that "the lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012)." The results of the study were published in the peer-reviewed British Journal of Sports Medicine.

The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. "Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack significantly increased (p<0.05) the leavator ani muscle".

Because of Eurycoma longifolia's testosterone-enhancing capacity, it has been included in numerous supplements marketed primarily to body building men. In gym circles, Eurycoma longifolia Jack is commonly referred to as Longjack.

Milk Thistle (SILYMARIN)

The milk thistle is a thistle of the genus Silybum Adans., a flowering plant of the daisy family (Asteraceae). They are native to the Mediterranean regions of Europe, North Africa and the Middle East. The name "milk thistle" derives from two features of the leaves: they are mottled with splashes of white and they contain a milky sap.

The seeds of the milk thistle have been used for 2000 years to treat chronic liver disease and protect the liver against toxins. Increasing research is being undertaken on the physiological effects, therapeutic properties and possible medical uses of milk thistle.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), toxin-induced liver damage, and gallbladder disorders.

Reviews of the literature covering clinical studies of silymarin vary. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases".

A different review of the literature performed for the U. S. Department of Health and Human Services found that while there is strong evidence of legitimate medical benefits, the studies done to date are of uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made.

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[13], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.

Beside benefits for liver disease, other unproven treatment claims include:

Used as a post (oral steroid) cycle therapy for body builders and/or in the hopes of reducing or eliminating liver damage

Lowering cholesterol levels

Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis

Reducing the growth of cancer cells in breast, cervical, and prostate cancers.

Used in many products claiming to reduce the effects of a hangover

Used by individuals withdrawing from opiates, especially during the Acute Withdrawal Stage.

Reducing liver damaging effects of chemotherapeutic drugs

Clinical study has shown that liver function tests can be improved in active hepatitis patients.

N-acetyl-L-cysteine (NAC)

Acetylcysteine, also known as N-acetylcysteine or N-acetyl-L-cysteine (abbreviated NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

Cysteine is an amino acid that can be found throughout the body. N-acetyl-L-cysteine (NAC), a modified form of cysteine, has been shown to increase levels of the antioxidant glutathione. Antioxidants such as glutathione can reduce cell damage, speed recovery from injury and aid muscle growth.

NAC is a popular supplement with a wide variety of uses. Because it reduces muscle damage and strengthens the immune system, NAC is used by endurance athletes such as long-distance runners, cyclists and triathletes. Many athletes include NAC in their diet when they are in the early stages of recovering from an injury.

The anabolic effect of NAC on muscle tissue also makes it popular with athletes wanting to gain lean muscle size and strength, including body builders, rugby players, and sprinters.