Liver Longer Information (On Cycle Support)
Serving Size: 1 tablet
Servings per Container: 60
Amount Per Serving:
Tauroursodeoxycholic acid (TUDCA) 250mg
Other Ingredients: Calcium phosphate, Sipernat 22, Steric Acid, Magnesium stearate, film coating.
Bottle recommended dosage: 1 tablet 2x per day with meals.
Company literature on Liver Longer claims Liver Longer specifically targets steroid toxicity and was developed to prevent the formation of toxic steroid metabolites, reverse the toxic actions of the metabolites that do get formed, and speed the elimination of the metabolites from the liver.
Liver Longer Ingredients
Calcium PhosphateCalcium phosphate is a mineral salt found in rocks and bones. It is used as a nutritional supplement and occurs naturally in cow milk, although the most common and economical forms for supplementation are calcium carbonate (which should be taken with food) and calcium citrate (which can be taken without food). There is some debate about the different bioavailabilities of the different calcium salts.
Magnesium StearateMagnesium stearate is often used as a diluent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets.
Magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, but not that it reduces the over-all bioavailability of those ingredients.
Sipernat 22Chemical Name: Silicon dioxide, chemically prepared
Sipernat 22 is a silica with spherical particles, low fines content and high oil absorption (DBP). In the food industry, Sipernat 22 is used as a carrier for aromas and other liquid constituents. It's also a free flow additive for direct use in spraying tower for drying various instant food products.
Stearic AcidStearic acid is the saturated fatty acid with an 18 carbon chain and has the IUPAC name octadecanoic acid. It is a waxy solid, and the salts and esters of stearic acid are called stearates. It occurs in many animal and vegetable fats and oils, but it is more common in animal fat. The important exceptions are cocoa butter and shea butter, whose fatty acids consist of 28–45% stearic acid.
Stearic acid is used in making candles, plastics, dietary supplements, oil pastels and cosmetics, softening rubber, and hardening soaps. Stearic acid is used in aerosol shaving cream products. It is used along with simple sugar or corn syrup as a hardener in candies and to form margarines, shortenings, spreads, and as a cream base for baked products.
Even though stearic acid is a saturated fat, studies have suggested that it has little effect on blood cholesterol levels, because such a high proportion is converted to oleic acid.
Tauroursodeoxycholic Acid (TUDCA)Tauroursodeoxycholic acid (TUDCA) is a liver aid introduced as a supplement by ThermoLife in their product Liver Longer. It looks like a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids.
Tauroursodeoxycholic acid is an anti-cholestatic agent, modulating protein kinase C (PKC) pathway. PKC reduces ischemic damage in several organs. Its isoform modulates ezrin, a key protein in the maintenance of cell lamellipoidal extensions.
TUDCA, a metabolite to UDCA (Ursodeoxycholic acid), is basically a particular Bile Acid enzyme that is naturally produced in the Liver. TUDCA has been proven in over 220 documented cases to dramatically improve both the performance of the liver as well as decrease pre-existing damage. TUDCA (Liver Longer) reduces the enzymatic stress on the liver. TUDCA/UDCA has been proven in double-blind study's to reduce enzymatic stress caused by methylation by an average of 41%.
A multicenter, cooperative study involving 12 hospitals throughout Italy evaluated the effects of long-term oral administration of TUDCA (500 mg/d for 3 months) on serum liver enzymes, total bilirubin, and serum lipid levels in patients with biopsy-proven chronic hepatitis due to hepatitis C virus (HCV) or hepatitis B virus (HBV) infection.
TUDCA was well tolerated and safe and was associated with a significant (P < 0.001) decrease in all serum liver enzyme levels. A slight improvement in total bilirubin levels was also observed. In addition, TUDCA caused a slight but significant improvement in serum lipid profiles.
These favorable changes were similar in HCV and HBV hepatitis and were independent of age, sex, body weight, and alcohol consumption. These results indicate TUDCA may have a place in the treatment of patients with chronic hepatitis, a possibility that needs to be verified by means of long-term, prospective, placebo-controlled, double-blind studies.