Forged: ATD Information (Test Boosters/Hormone Regulation)

Forged: ATD by Transform Supplements


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Ingredients
Manufactured by:
Transform Supplements

Serving Size: 1 capsule
Servings per Container: 90

Ingredients:
ATD - 3, 17-keto etiochol-triene 25mg

Proprietary Blend: 325mg
325mg Acai Berry 4:1
Green Tea Extract (50% Catechins)
Pomegranate Fruit (40% Ellagitannins)
Grape Seed Extract (95% OPC)
Resveratrol 50% (From Polygonum cuspidatum)
Na R-Alpha Lipoic Acid (NaR-ALA)
Quercetin (Quercetin Dihydrate)
Coenzyme Q10 (CoQ10 Natural)

Bottle recommended dosage: 1 capsule daily. Do not exceed four weeks of continuous use. After four weeks of use, follow with atleast a four week break.

The body converts extra test into estrogen through the enzyme aromatase and it down-regulates natural production through feedback with the hypothalamus. This is where ATD comes in to play. It deactivates aromatase by irreversibly binding to it, and it confuses hypothalamus regulation by blocking its testosterone receptors.

Our special proprietary blend adds additional anti-aromatase activity, increases testosterone production, increases estrogen clearance, promotes thermogenesis, and provide anti-oxidant support.

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1-4-6 androstatriene-3-17-dione (ATD)

1-4-6 androstatriene-3-17-dione (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. It is used to control estrogen synthesis.

ATD is present in some over-the-counter bodybuilding supplements as well as Topical ATD solutions that work transdermally.

While not banned, ATD may cause positive urinalysis results. ATD may cause a positive test for the anabolic steroid boldenone, of which it is a metabolite and is also prohibited in amateur and professional sports which forbids aromatase inhibitors.

A related agent is Exemestane (Aromasin).

Acai Berry

The acai berry is an inch-long reddish, purple fruit. It comes from the acai palm tree (Euterpe oleracea), which is native to Central and South America. It is a relative of the blueberry, cranberry, and other dark purple fruits. Research on the acai berry has focused on its possible antioxidant activity. Theoretically, that activity may help prevent diseases caused by oxidative stress such as heart disease and cancer.

Acai contains several substances called anthocyanins and flavonoids. Anthocyanins are responsible for the red, purple, and blue hues in many fruits, vegetables, and flowers. Foods that are richest in anthocyanins are strongly colored, ranging from deep purple to black. Anthocyanins and flavonoids are powerful antioxidants that play a role in the body's cell protection system. By lessening the destructive power of free radicals, antioxidants may help reduce the risk of some diseases.

Some studies show that acai fruit pulp has even more antioxidant content than cranberry, raspberry, blackberry, strawberry, or blueberry. People eat acai berries to address various health conditions, but so far, acai berries have no known health benefit that's any different than that of other similar fruits.

Coenzyme Q10

Coenzyme Q10 (CoQ10) is a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS.

CoQ10 is involved in making an important molecule known as adenosine triphosphate (ATP). ATP serves as the cell's major energy source and drives a number of biological processes, including muscle contraction and the production of protein. CoQ10 also works as an antioxidant.

Clinical research suggests that using coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat heart disease, high blood pressure, high cholesterol, and diabetes.

Primary dietary sources of CoQ10 include oily fish, organ meats, and whole grains. Most individuals obtain sufficient amounts of CoQ10 through a balanced diet, but supplementation may be useful for individuals with particular health conditions or taking certain medications.

Grape Seed Extract

Grape seed extracts are derivatives from whole grape seeds that have a concentration of vitamin E, flavonoids, linoleic acid, and OPCs.

Preliminary studies in humans and animals show grape seed extract may be useful to treat high blood pressure and high cholesterol. By limiting lipid oxidation, phenolics in grape seeds may reduce risk of heart disease, such as by inhibiting platelet aggregation and reducing inflammation. A polyphenol contained in grape seeds is resveratrol which may interfere with cancer cell growth and proliferation, as well as induce apoptosis, among a variety of potential preventive effects.

Currently, there are clinical trials underway to assess the effect of grape seed extracts on human breast cancer, blood estrogen levels in postmenopausal women, and coronary artery disease.

Of note to strength athletes, grape seed extract is also an aromatase inhibitor; it suppresses the conversion of testosterone to estradiol.

Green Tea Extract

Green tea extract is a herbal derivative from green tea leaves (Camellia sinensis). Containing antioxidant ingredients ? mainly green tea catechins (GTC) ? green tea and its derivatives are sought-after amongst people who pursue health.

Green tea extracts exhibit stronger antioxidant protection for human body than vitamin C and vitamin E. Scavenging effect of lipid free-radicals (one antioxidant property) of polyphenols in green tea extracts can be clearly observed in experiments. The ability of GTP in green tea extracts to eliminate lipid-derived free radicals is noticeably stronger (almost 50 times) than that of ginkgo biloba extracts.

Further investigations indicate that the boosting level of superoxide dismutase (SOD) and glutathione dismutase (GSHPx) may account for the inhibitory effect of GTC against lipid oxidation (rancidification). It should be mentioned that from the antioxidant perspective, green tea extracts are, generally speaking, more effective than black tea extracts due to the better preservation of catechins.

The anticarcinogenic property make the green tea extracts a hotspot in recent scientific researches. In many experiments, green tea extracts show inhibitory effects on cancer cells. In vitro assays, Catechin and caffeine, which are main components in green tea extracts, block the cell cycle of cancer cells (cytotoxicity) and induce programmed cell death.

Green tea extracts also contain a wide-ranged anti-inflammatory characteristics, so it may be helpful in treating chronic inflammatory states.

Pomegranate

A pomegranate (Punica granatum) is a fruit-bearing deciduous shrub or small tree growing between five and eight meters tall.

Pomegranate is a good source of vitamin C, vitamin B5 (pantothenic acid), potassium, and polyphenols such as tannins and flavonoids. The most abundant polyphenols in pomegranate juice are the hydrolyzable tannins called ellagitannins formed when ellagic acid binds with a carbohydrate. Punicalagins are tannins with free-radical scavenging properties in laboratory experiments. Punicalagins may have dietary value as antioxidants, but conclusive proof of efficacy in humans has not yet been shown.

Other phytochemicals include polyphenolic catechins, gallocatechins, and anthocyanins, such as prodelphinidins, delphinidin, cyanidin, and pelargonidin. The ORAC (antioxidant capacity) of pomegranate juice was measured at 2,860 units per 100 grams.

Many food and dietary supplement makers use pomegranate phenolic extracts as ingredients in their products. One of these extracts is ellagic acid, which may become bioavailable only after parent molecule punicalagins are metabolized. However, ingested ellagic acid from pomegranate juice does not accumulate in the blood in significant quantities and is rapidly excreted.

In preliminary laboratory research and human pilot studies, juice of the pomegranate was effective in reducing heart disease risk factors, including LDL oxidation, macrophage oxidative status, and foam cell formation, all of which are steps in atherosclerosis and cardiovascular disease.

In a limited study of hypertensive patients, consumption of pomegranate juice for two weeks was shown to reduce systolic blood pressure by inhibiting serum angiotensin-converting enzyme. Juice consumption may also inhibit viral infections while pomegranate extracts have antibacterial effects against dental plaque.

Despite research being preliminary, manufacturers and marketers of pomegranate juice have results for promotion, especially for antioxidant health benefits.

Quercetin

Quercetin (a flavonol) is a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods.

Several studies show quercetin may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin may have inhibitory properties against cancer, prostatitis, heart disease, cataracts, allergies/inflammations, and respiratory diseases, such as bronchitis and asthma. It has also been claimed that quercetin reduces blood pressure in hypertensive subjects. An in vitro study showed that quercetin and resveratrol combined inhibited production of fat cells.

Despite preliminary indications of possible medicinal effects, quercetin has neither been confirmed as a specific therapeutic for any condition nor has it been approved by any regulatory agency. A bioavailability study done on rats showed that ingested quercetin is extensively metabolized into non-active phenolic acids, with more than 96% of the ingested amount excreted within 72 hours, indicating actual physiological roles, if they exist, involve quercetin in only minute amounts.

Resveratrol

Resveratrol is a stilbenoid, a type of polyphenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi.

Resveratrol is currently a topic of numerous studies. In mouse and rat experiments, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported. Most of these results have yet to be replicated in humans. Despite mainstream press alleging resveratrol's anti-aging effects, there is little scientific basis for these claims.

Resveratrol is found in the skin of red grapes and is a constituent of red wine. Resveratrol has also been produced by chemical synthesis or by biotechnological synthesis (metabolic engineered microorganisms) and is sold as a nutritional supplement derived primarily from Japanese knotweed.

A compound that binds to estrogen receptors and elicits similar responses to endogenous estrogens is considered an estrogen agonist, while a compound that binds estrogen receptors but prevents or inhibits the response elicited by endogenous estrogens is considered an estrogen antagonist. The chemical structure of resveratrol is very similar to that of the synthetic estrogen agonist, diethylstilbestrol, suggesting that resveratrol might also function as an estrogen agonist. However, in cell culture experiments resveratrol acts as an estrogen agonist under some conditions and an estrogen antagonist under other conditions. In estrogen receptor-positive breast cancer cells, resveratrol acted as an estrogen agonist in the absence of the endogenous estrogen, 17beta-estradiol, but acted as an estrogen antagonist in the presence of 17beta-estradiol.

At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens.

R-Lipoic Acid (RLA)

Lipoic acid is an organosulfur compound derived from octanoic acid. The carbon atom at C6 is chiral and the molecule exists as two enantiomers R-(+)-lipoic acid (RLA) and S-(-)-lipoic acid (SLA) and as a racemic mixture R/S-lipoic acid (R/S-LA). Only the R-(+)-enantiomer exists in nature and is an essential cofactor of four mitochondrial enzyme complexes.

Endogenously synthesized RLA is essential for life and aerobic metabolism. Both RLA and R/S-LA are available as over-the-counter nutritional supplements and have been used nutritionally and clinically since the 1950s.

Lipoic acid restored liver glycogen and the sulfhydryl content in physiological and experimental hepato-pathologic conditions, but was ineffective in treating portal cirrhosis or alloxan-induced diabetes. Dr P. Introzzi (University of Pavia) presented case histories of four cases of hepatic cirrhosis, two of congestive heart failure and two of chronic hepatitis. One case of hepatic cirrhosis and both cases of chronic hepatitis responded favorably.

LA was shown to be hepatoprotective, improve liver circulation, treat chronic liver diseases, various liver diseases such as jaundice, hepatitis, cirrhosis, hepatic coma, diabetes, alter carbohydrate metabolism, diabetic neuropathy, alter histidine metabolic disorders, atherosclerosis, coronary atherosclerosis, ethionine-damaged liver, experimentally reduce voluntary alcohol intake, and augment potassium tolerance.

Since the mid-1950s the overlapping nutritional and clinical uses of Lipoic acid have been recognized and commercially developed. The original rationale for using R/S-lipoic acid (LA) as a nutritional supplement was that endogenous RLA was known to have biochemical properties like a B-vitamin (acting as a substrate or co-factor essential for enzyme function). It was also recognized that lower endogenous concentrations of RLA were found in tissues of humans with various diseases and lower levels of RLA were found in the 24 hour urine of patients with various diseases than in healthy subjects.

The exact mechanisms of how RLA levels decline with age and in various progressive diseases is unknown. In addition, microbial assays used to quantify LA were essentially stereospecific for RLA (100% active for RLA, 0% activity for SLA) so it was believed that SLA was essentially inert or of very low biological activity. This was proven false by Gal who demonstrated stereospecific toxicity of the S-enantiomer in thiamine-deficient rats.

Lipoic acid was recognized to have antioxidant potential in 1959 and was used as a preservative for lard and cooking oils but it would take another 40 years for this property to gain significant public attention and application in maintaining or restoring human health.

Japanese and German manufactured R/S-LA became available as a nutritional supplement in the US in the late 80?s and sales and use grew slowly and steadily throughout the 1990s as interest in antioxidants and free radicals grew due to recognition of the roles of reactive oxygen and reactive nitrogen species in health, disease and the aging process.

Demand grew for RLA along with R/S-LA after several papers by research group of Professor Bruce Ames (from UC Berkeley) found RLA and acetyl carnitine reversed age-related markers in old rats to youthful levels.

Today R/S-LA and RLA are widely available as over-the-counter nutritional supplements in the United States in the form of capsules, tablets and aqueous liquids and have been branded as antioxidants. In Japan LA is marketed primarily as a "weight loss" and "energy" supplement.

RLA may function in vivo like a B-vitamin and at higher doses like plant derived nutrients such as curcumin, sulphoraphane, resveratrol, other nutritional substances that induce phase II detoxification enzymes, thus acting as cytoprotective agents.

A recent human pharmacokinetic study of RLA demonstrated that the maximum co