Prohormone & Supplement Ingredients:

Prunella vulgaris

Prunella vulgaris (known as common self-heal or heal-all) is an herbaceous plant in the genus Prunella. It is edible and the young leaves and stems can be eaten raw in salads. The whole plant can be boiled and eaten, and the aerial parts of the plant can be powdered and brewed.

Medicinally, the whole plant is poulticed onto wounds to promote healing. A mouthwash made from an infusion of the whole plant can be used to treat sore throats, thrush and gum infections. Internally, a tea can be used to treat diarrhea and internal bleeding.

By screening multiple herbs using the endometrial cancer cell line, ECC-1, and an alkaline phosphatase detection assay, PV displayed significant antiestrogenic activity.

The possible usefulness of antiestrogenic activity was investigated using both in vitro and in vivo models of endometrial function. PV extract, at concentrations that were not toxic to the cells, significantly reduced alkaline phosphatase activity and cell proliferation in response to estrogen in a dose-dependent manner.

The expression of CYR61, an estrogen-induced protein, was blocked. Interestingly, PV extract did not appear to directly inhibit estrogen signaling. Rather, its activities were probably related to an ability to function as an aryl hydrocarbon receptor agonist in ECC-1 cells.

Prunella vulgaris induced CYP1A1, CYP1B1, and AHR repressor expression in a dose-dependent manneróresponses that were blocked by small interfering RNA treatment to reduce AHR and specific AHR antagonists.

Prunella vulgaris exhibits significant antiestrogenic properties, both in vitro and in vivo. This activity is likely due to the ability of Prunella vulgaris activated AHR to interfere with estrogen.

This herb may be useful as an adjunct for the treatment of estrogen-dependent processes like endometriosis and breast and uterine cancers.
Supplements with this ingredient:
None (for now)

Links to additional information on Prunella vulgaris
Characterization of Antiestrogenic Activity of the Chinese Herb, Prunella vulgaris (Added on 3/20/2013 5:22:00 PM)
Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation (Added on 3/20/2013 5:22:00 PM)
Anti-estrogen Activity of Prunella Vulgaris on an Endometrial Cell Line (Added on 3/20/2013 5:27:00 PM)

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