Prohormone & Supplement Ingredients:

Estra-4,9,11-triene-3,17-dione (Trenavar)

Estra-4,9,11-triene-3,17-dione (Trenavar, Trendione) was released in late 2011 by PHF/IBE and is represented as a true prohormone to Trenbolone, differing only by a ketone at the 17 position. Similar to other 17-one prohormones, this ketone is the target of 17b-HSD1, hydrogenating the compound to yield active Trenbolone.

Information cited in the write-up argues that this compound is orally bioavailable. Tren is known to have a high affinity for the androgen receptor and also functions as a glucocorticoid receptor antagonist. This is powerful stuff.

From HenryV:

Function:

This is a prohormone to the veterinary drug and black-market bodybuilding steroid trenbolone. Unlike previous "tren" prohormones, this one actually converts in the body to trenbolone. Previous "tren" PHs converted to the structurally similar but markedly weaker steroid dienolone.

Structure:

This prohormone has the same three conjugated double bonds as trenbolone, and differs from it only in that this hormone has a 17-ketone, where trenbolone has a 17b-hydroxy function. In the body this ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5) into the active form, trenbolone.

Effects:

Conversion to trenbolone should be high, so effects should be identical to the injectable form with the exception of the famed "tren cough". Whatever the explanation for "tren cough" (and many have been suggested), since it's a reaction to the sudden parenteral introduction of some compound directly into the body, it's highly unlikely that any orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same: huge strength and size increases, accelerated fat loss, and enhanced vascularity.

Side Effects:

Blood pressure is likely to be dose-dependently elevated to a significant degree, cholesterol levels and liver function markers are likely to be adversely affected, though to what extent remains to be seen. Commonly reported trenbolone sides include night-sweats, mood swings, androgenic hair loss and/or growth, temporary loss of libido, as well as the suppression of endogenous testosterone production. It would be sensible to assume that these may also result from use of Trenavar.

Metabolism and Bioavailability:

The anabolic effects of trenbolone are due in part to the enhanced androgen receptor binding that the conjugated double bond system causes [1], and also because trenbolone is an antagonist of the glucocorticoid receptor [2]. The double bonds extending up the backbone of the steroid flattens the steroid considerably, which makes it an excellent fit for the androgen receptor. It also makes the molecule much more flexible, and therefore less receptor-specific [3]. Trenbolone is incapable of being affected by 5a-reductase, 5b-reductase, or aromatase. But will it work orally?

The first place to turn to for information on steroids is the seminal 1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately this compound isn't among the 666 compounds discussed there, and there's a shortage of information on trenbolone by oral adminstration. I was fortunate enough to find a study which compared the anabolic effects of oral and subcutaneous application of trenbolone in rats [4], and the results were frankly startling. They found that to have a comparable anabolic effect, trenbolone needed to be administered orally at 100 times the dosage as when administered by subcutaneous injection (see graph). Sounds pretty bad for a tren PH then, right? Well, the good news is we're not rats.


Trenbolone is metabolised differently in different species - in rats, around 40% is excreted as a dione form, as well as several metabolites hydroxylated in various<
Supplements with this ingredient:
Estrastain (Prohormones)
Mammoth DNA (Prohormones)
Pro Trenazine (Prohormones)
Reaper (Prohormones)
Trenavar (Prohormones)
Winsdrol Xtreme (Prohormones)
Xtreme Tren SD (Prohormones)
Xtreme Tren Six (Prohormones)

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