Prohormone & Supplement Ingredients:

Diindolylmethane (DIM)

Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables which promotes a beneficial estrogen metabolism in both women and men. There are also indication that is possesses anti-cancer properties, and as well as being an anti-viral.

The National Cancer Institute of the United States has begun clinical trials of DIM to look at its anti-cancer properties. DIM is also being looked at as treatment for viral infections and antibiotic resistant bacteria.

DIM is currently used to treat Recurring Respiratory Papillomatosis, a rare respiratory disease with tumors in the upper respiratory tracts caused by the human papilloma virus. DIM is also in Phase III clinical trials for cervical dysplasia, a pre-cancerous condition also caused by the human papilloma virus. Similarly, it has been studied and shown promising results as a immunostimulant against HPV.

As a dimer of indole-3-carbinol, diindolylmethane promotes beneficial estrogen metabolism in both genders by reducing 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites.

There are claims that Diindolylmethane is the most active cruciferous substance for promoting beneficial estrogen metabolism in women and men. DIM is formed from its precursor indole, Indole-3-carbinol (I3C), after the enzymatic release of I3C from parent glucosinolates. Early experiments demonstrated animal diets with added DIM prevented chemically induced cancer.

Pure DIM was first used in 1987 as a dietary supplement in animals, was shown to be non-toxic, and to be a breast cancer preventative. The mechanisms by which DIM prevents cancer in animals has subsequently been shown to involve a reduction in activity of the estrogen receptor system, promotion of beneficial estrogen metabolism, and support for selective apoptosis, or "programmed cell death" which removes damaged cells.

Supplemental use of DIM in humans is effective in adjusting the pathways of estrogen metabolism to favor the production of 2-hydroxy estrogen metabolites. These shifts in estrogen metabolites were significant and showed an approximate 75% increase in production of 2-hydroxyestrone and a 50% decrease in 16-hydroxyestrone. An increased proportion of 2-hydroxy metabolites is correlated to protection from breast cancer. Case-control studies have documented that low levels of 2-hydroxy metabolites are associated with various types of cancers in both menand women.

DIM is unique among all phytonutritionals with regard to its ability to favorably modify estrogen metabolism in the direction of greater 2-hydroxy estrogen production.

So I found research that claim DIM is an:

aromatase inhibitor
anti-estrogen
estrogen convertor

Which one is it really? I'm afraid I'm not sure.
Supplements with this ingredient:
RA Silver Bullet PCT System (Post Cycle Support)
Stage II Evolution PCT Rejuvenation (Post Cycle Support)

Links to additional information on Diindolylmethane (DIM)
Safer Estrogen with Phytonutrition (Added on 2/10/2011)
INDOLE-3-CARBINOL (I3C) and DIINDOLYLMETHANE (DIM) ABSTRACTS (Added on 2/10/2011)
diindolylmethane (Added on 2/10/2011)
Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist (Added on 2/10/2011)
Diindolylmethane in Treating Patients With Stage I or Stage II Prostate Cancer (Added on 2/10/2011)
diindolylmethane supplements on urinary hormone metabolites in postmenopausal women (Added on 2/10/2011)
controlled safety study of diindolylmethane in the immature rat model (Added on 2/10/2011)
Diindolylmethane in Treating Patients With Abnormal Cervical Cells (Added on 2/10/2011)

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