ChrysinChrysin (5,7-Dihydroxyflavone) is a flavonoid extracted from the plant Passiflora coerulea, a member of the passion flower family. It is promoted in bodybuilding to be an effective aromatase inhibitor. Aromatase causes the conversion of testosterone into estradiol and androstenedione into estrone.
Chrysin is widely sold in the supplement industry despite the fact that no real-life studies have been able to substantially prove its effectiveness in humans. Studies done in-vivo show that orally administered chrysin does not have clinical aromatase inhibitor activity.
Studies observed chrysin has no effect on estrogen levels, but may have other detrimental effects to the body, particularly to thyroid function. A 30 day study administered chrysin to four groups of mice both orally and via injection to examine chrysin's effect on serum estrogen levels. The results showed chrysin had no effect on estrogen levels. Further, the mice treated with chrysin became considerably fatter, possibly due to chrysin's ability to disrupt thyroid function.
Another study on rats administered 50 mg of chrysin per kg body weight, considerably more than found in dietary supplements. Chrysin was found to have no ability to inhibit aromatase, possibly due to poor absorption or bioavailability.
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Links to additional information on Chrysin
Inhibition of human estrogen synthetase (aromatase) by flavones (Added on 1/22/2011)
Disposition and metabolism of the flavonoid chrysin in normal volunteers (Added on 1/22/2011)
Does Chrysin Work As An Estrogen Blocker? (Added on 1/22/2011)
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