Prohormone & Supplement Ingredients:

Brassaiopsis Glomerulata

Brassaiopsis glomerulata is a large shrub or small tree with several reported medicinal uses.

In Vietnam, the plant is used to treat rheumatism and back pain. In India, a juice extract is said to aid digestion and alleviate constipation. This species is also used medicinally in China to promote urination and assist in lactation.

Brassaiopsis glomerulata was tested using in vivo anti-inflammatory, antipyretic, and diuretic models. Brassaiopsis glomerulata is reported to inhibit carrageenan-induced swelling of rat paws (anti-inflammatory) and induce an antipyretic effect using a rat fever model induced by beer yeast or carrageenan. No diuretic effect was reported.

Aromatase is the enzyme responsible for catalyzing the biosynthesis of estrogens (estrone and estradiol) from androgens (androstenedione and testosterone). Inhibition of aromatase has been shown to reduce estrogen production to nearly undetectable levels. Aromatase inhibitors are being used clinically to retard the development and progression of hormone-responsive breast cancers. FDA approved aromatase inhibitors include anastrozole, letrozole, and exemestane.

The hexane- and ethyl acetate-soluble extracts of the leaves of Brassaiopsis glomerulata were found to inhibit aromatase, the rate-limiting enzyme in the production of estrogens from androgens, in both enzyme- and cell-based aromatase inhibition (AI) assays.

Brassaiopsis glomerulata, as mentioned earlier, has been reported to have various ethnobotanical uses. The past history of medicinal use by human populations may be indicative of being safe when consumed.

The strong aromatase inhibition of the hexane extract in both enzyme- and cell-based assays, coupled with the possibility of a favorable safety profile, may point to the potential for use for the chemoprevention of breast cancer.

Further investigations are needed, including a recollection and subsequent bioassay-guided compound isolation, as well as further biological studies on the mechanism of aromatase inhibition and in vivo testing.
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Links to additional information on Brassaiopsis Glomerulata
Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Added on 3/20/2013 5:15:00 PM)

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