Prohormone & Supplement Ingredients:

Bergamottin

Bergamottin is a natural furanocoumarin found principally in grapefruit juice. It is also found in the oil of bergamot, from which it was first isolated and from which its name is derived. To a lesser extent, bergamottin is also present in the essential oils of other citrus fruits. Along with the chemically related compound 6,7-dihydroxybergamottin, it is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.

6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 M). It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents. However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
Supplements with this ingredient:
Finaflex 1-Andro (Prohormones)
Finaflex 550-XD (Prohormones)
MethylDrol (Prohormones)

Links to additional information on Bergamottin
grapefruit and bergamottin (Added on 12/28/2010)
Bergamottin and its Role as a Drug Inhibitor (PDF) (Added on 12/28/2010)

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