Prohormone & Supplement Ingredients:

4-Androstene-3,6,17-trione (6-OXO)

Nutritional supplements designed with the intent of inhibiting aromatase activity are relatively new to the fitness community. Examples of these supplements are 6-OXO and Novedex XT, and are alleged to act similar to such aromatase inhibiting drugs as formestane. It was recently shown that eight weeks of supplementation with the aromatase inhibiting nutritional supplement Novedex
XT (hydroxyandrost-4-ene-6,17-dioxo-3-THP ether and 3,17-diketo-androst-1,4,6-triene) was effective at increasing serum testosterone and DHT, while only displaying slight increases in estrogen levels. Additionally, compounds with the same (androst-4-ene-3,6,17-trione) and very similar (androst-5-ene-4,7,17-trione) structure as 6-OXO have been shown to irreversibly bind to the aromatase enzyme thereby causing a decrease in estradiol production. Therefore, use of these aromatase-inhibiting compounds seem to decrease aromatization and subsequent estradiol synthesis, which apparently increases both TST and T/E.

In regard to body composition, neither dose of 6-OXO demonstrated any significant improvement in fat mass or fat-free mass over the course of the study. Even with significant increases in FT and DHT, this furthers indicates that 6-OXO supplemented at these dosages for eight weeks did not decrease fat mass or cause an anabolic response by increasing muscle mass.

The results of this study indicate that eight weeks of 6-OXO supplementation had no effect on body composition or clinical safety markers, but incompletely inhibited aromatase activity and significantly increased endogenous DHT levels that were attenuated after a three-week washout period. Therefore, while neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.
Supplements with this ingredient:
None (for now)

Links to additional information on 4-Androstene-3,6,17-trione (6-OXO)
Effects of eight weeks of supplement 6-OXO (Added on 4/11/2012)
4-Androstene-3,6,17-trione (Added on 4/11/2012)
Muscle & Fitness: The science of 6-OXO (Added on 4/11/2012)
World Anti-Doping Code (Added on 4/11/2012)

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