Prohormone & Supplement Ingredients:

3beta-hydroxy-5-pregnen-20-one (Pregnenolone)

Pregnenolone is a progestin, a synthetic progestogen that has progestinic effects similar to progesterone.

The two most common uses of progestins are for hormonal contraception and to prevent endometrial hyperplasia from unopposed estrogen in hormone replacement therapy. Progestins are also used to treat secondary amenorrhea, dysfunctional uterine bleeding and endometriosis, and as palliative treatment of endometrial cancer, renal cell carcinoma, breast cancer, and prostate cancer.

Pregnenolone is involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. As such it is a prohormone, though it also has biological effects of its own.

Pregnenolone can be easily converted into DHEA which in turn is converted into androgens, estrogens and other steroids. It can also be metabolized into progesterone which in turn can turn into aldosterone or cortisol.

This makes Pregnenolone different from DHEA. It has the ability to form other hormones such as progesterone. DHEA has often been called the "Mother hormone." I call Preg "The mother of DHEA, and Grandmother of all steroid hormones."

When you take Preg, your body will decide which pathway it will take. Will it go the DHEA way, or progesterone/cortisol/aldosterone direction?

In 1943, Hans Selye, wrote: Pregnenolone distinguishes itself from other steroids because it possesses so many different activities. Thus the compound possesses, at least in traces, every independent main pharmacological action which has hitherto been shown to be exhibited by any steroid hormone.

In the light of these observations it was tempting to speculate on the possible role of the compound as an hormone-precursor from which the organism may, according to its needs, produce compounds in which one effect is particularly developed at the expense of other activities of the parent substance. One advantage that Pregnenolone has over DHEA is that it is less androgenic, that is, individuals who get acne or facial hair from DHEA would be much less likely to do so on Pregnenolone.
Supplements with this ingredient:
None (for now)

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